Phosphorylation of L1 by CK-II

Stable Identifier
R-HSA-392752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of L1 by CK-II
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CKII phosphorylates L1CAM at serine 1181, just after the AP-2 recognition site (Y1176RSLE motif). CKII-dependent phosphorylation of S1181 has been shown to regulate trafficking of the internalized L1 and subsequent axon growth.
Literature References
PubMed ID Title Journal Year
17253643 Serine phosphorylation by casein kinase II controls endocytic L1 trafficking and axon growth

Nakata, A, Kamiguchi, H

J Neurosci Res 2007
8592152 Casein kinase II phosphorylates the neural cell adhesion molecule L1

Landreth, G, Schaefer, AW, Lemmon, V, Wong, EV

J Neurochem 1996
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Catalyst Activity

protein serine/threonine kinase activity of Casein kinase II [cytosol]

Physical Entity
Casein kinase II [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of L1 by CK-II (Caenorhabditis elegans)
Phosphorylation of L1 by CK-II (Mus musculus)
Phosphorylation of L1 by CK-II (Rattus norvegicus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-03-07)
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