Phosphorylation of L1 by CK-II

Stable Identifier
R-HSA-392752
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of L1 by CK-II
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CKII phosphorylates L1CAM at serine 1181, just after the AP-2 recognition site (Y1176RSLE motif). CKII-dependent phosphorylation of S1181 has been shown to regulate trafficking of the internalized L1 and subsequent axon growth.

Literature References
PubMed ID Title Journal Year
17253643 Serine phosphorylation by casein kinase II controls endocytic L1 trafficking and axon growth

Nakata, A, Kamiguchi, H

J Neurosci Res 2007
8592152 Casein kinase II phosphorylates the neural cell adhesion molecule L1

Landreth, G, Schaefer, AW, Lemmon, V, Wong, EV

J Neurochem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Casein kinase II [cytosol]

Physical Entity
Casein kinase II [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of L1 by CK-II (Caenorhabditis elegans)
Phosphorylation of L1 by CK-II (Drosophila melanogaster)
Phosphorylation of L1 by CK-II (Mus musculus)
Phosphorylation of L1 by CK-II (Rattus norvegicus)
Phosphorylation of L1 by CK-II (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-03-07)
Cite Us!