PRC1 SUMOylates CASP8AP2 with SUMO1

Stable Identifier
R-HSA-3927824
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Pc2 SUMOylates FLASH
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The CBX3 component of PRC1 SUMOylates CASP8AP2 (FLASH) at lysine-1813 with SUMO1 (Alm-Kristiansen et al. 2009). SUMOylation enhances the transcriptional coactivation activity of CASP8AP2. SUMOylation also appears to trigger proteasomal degradation of CASP8AP2 (Vennemann and Hofmann 2013).
Literature References
PubMed ID Title Journal Year
23673342 SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2

Hofmann, TG, Vennemann, A

Cell Cycle 2013
19615980 SUMO modification regulates the transcriptional activity of FLASH

Gabrielsen, OS, Alm-Kristiansen, AH, Matre, V, Norman, IL

Biochem. Biophys. Res. Commun. 2009
Participants
Participates
Catalyst Activity

SUMO transferase activity of PRC1 complex [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!