Reactome | monoSUMO1-K1813-CASP8AP2 [nucleoplasm]

monoSUMO1-K1813-CASP8AP2 [nucleoplasm]

Stable Identifier

R-HSA-3927850

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CASP8-associated protein 2, C8AP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UKL3 CASP8AP2

Gene Names

CASP8AP2, FLASH, KIAA1315, RIP25

Chain

initiator methionine:, chain:2-1982

Reference Genes

BioGPS Gene:9994 CASP8AP2

COSMIC (genes):CASP8AP2 CASP8AP2

CTD Gene:9994 CASP8AP2

dbSNP Gene:9994 CASP8AP2

ENSEMBL:ENSG00000288475 CASP8AP2

HGNC:1510 CASP8AP2

Monarch:9994 CASP8AP2

NCBI Gene:9994 CASP8AP2

OMIM:606880 CASP8AP2

UCSC:Q9UKL3 CASP8AP2

Reference Transcript

Other Identifiers

11756721_a_at

17010991

222201_3p_s_at

222201_PM_s_at

222201_s_at

2916959

2916960

2916961

2916972

2916973

2916974

2916975

2916976

2916977

2916978

2916982

2916983

2916985

2916986

2916987

2916988

2916990

72066_at

75979_at

8121118

89975_r_at

9994

A_14_P127718

A_23_P58898

A_33_P3382959

GE58462

GO:0003714

GO:0005123

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0006355

GO:0006915

GO:0006919

GO:0007165

GO:0008625

GO:0008656

GO:0012501

GO:0016505

GO:0016605

GO:0032184

GO:0036337

GO:0043226

GO:0045892

GO:0060090

GO:0071260

GO:0097190

GO:0098772

GO:0140110

HMNXSV003006896

Hs.122843.1.S1_3p_a_at

Hs.122843.1.S1_3p_x_at

ILMN_1747129

PH_hs_0006878

TC06000800.hg

p14609

Participates

as an output of

Other forms of this molecule

CASP8AP2 [nucleoplasm]

Inferred To

monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (Gallus gallus)

Casp8ap2 [nucleoplasm] (Mus musculus)

Casp8ap2 [nucleoplasm] (Rattus norvegicus)

CASP8AP2 [nucleoplasm] (Bos taurus)

CASP8AP2 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 1813

Coordinate

1813

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

ENSEMBL

ENSP00000518371, ENST00000671703

OpenTargets

ENSG00000118412

PRO

Q9UKL3

Pharos - Targets

Q9UKL3

GlyGen

Q9UKL3

PDB

6AP0, 6ANO, 6AOZ, 2LR8

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.704	5
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.602	5
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342)	0.553	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.508	4