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TUBA1C folding intermediate [cytosol]
Stable Identifier
R-HSA-392798
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
alpha tubulin 6 folding intermediate
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding (Homo sapiens)
Formation of tubulin folding intermediates by CCT/TriC (Homo sapiens)
Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC (Homo sapiens)
tubulin-GTP folding intermediate [cytosol] (Homo sapiens)
alpha/beta tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-> Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-> Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi (Homo sapiens)
beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E : Cofactor C [cytosol] (Homo sapiens)
beta tubulin:GTP: Cofactor D:alpha tubulin:GTP:Cofactor E [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Homo sapiens)
Cofactor B:GTP-alpha tubulin [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP + Cofactor E -> alpha-tubulin:GTP:Cofactor E (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B (Homo sapiens)
Cofactor B:GTP-alpha tubulin [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
Cofactor E:GTP-alpha tubulin folding [cytosol] (Homo sapiens)
GTP-alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
TUBA1C folding intermediate [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BQE3 TUBA1C
Gene Names
TUBA1C, TUBA6
Chain
chain:1-449, chain:1-448
Reference Genes
BioGPS Gene:84790 TUBA1C
COSMIC (genes):TUBA1C TUBA1C
CTD Gene:84790 TUBA1C
dbSNP Gene:84790 TUBA1C
ENSEMBL:ENSG00000167553 TUBA1C
HGNC:20768 TUBA1C
KEGG:hsa:84790 TUBA1C
Monarch:84790 TUBA1C
NCBI Gene:84790 TUBA1C
UCSC:Q9BQE3 TUBA1C
Reference Transcript
RefSeq:NM_032704.4 TUBA1C
Other Identifiers
11756670_x_at
11758282_s_at
209251_PM_x_at
209251_x_at
211750_PM_x_at
211750_x_at
212639_PM_x_at
212639_x_at
2872626
3344242
3413802
3413807
3413809
3413815
3413816
3413817
3413818
3413819
3413821
3413822
3413823
3413824
3413825
3413826
3413828
3413830
3413848
3453740
3453741
3453742
3453743
3453748
3453749
3453844
3453845
3453847
3453848
3453849
7955179
84790
A_23_P128154
A_23_P128161
A_24_P188071
GE83486
GO:0000226
GO:0000278
GO:0003824
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0005881
GO:0007010
GO:0007017
GO:0015630
GO:0016787
GO:0030705
GO:0031982
GO:0043226
GO:0045121
GO:0046872
GO:0051301
HMNXSV003040281
HMNXSV003046005
ILMN_1742167
PH_hs_0028341
TC12000363.hg
TC12000367.hg
TC12002866.hg
g13436316_3p_s_at
Participates
as a member of
alpha-tubulin folding intermediate [cytosol] (Homo sapiens)
Other forms of this molecule
AcK-TUBA1C [cytosol]
Ac K40 TUBA1C [axonemal microtubule]
TUBA1C unfolded [cytosol]
L-isoglutamyl polyglycyl-TUBA1C [cytosol]
Polyglutamyl-TUBA1C [cytosol]
TUBA1C(1-448) [cytosol]
TUBA1C [axonemal microtubule]
TUBA1C [cytosol]
Cross References
RefSeq
NP_116093.1
ENSEMBL
ENSP00000301072
,
ENST00000301072
OpenTargets
ENSG00000167553
HPA
ENSG00000167553-TUBA1C
PRO
Q9BQE3
Pharos - Targets
Q9BQE3
GlyGen
Q9BQE3
HMDB Protein
HMDBP08595
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.556
3
UniProt:Q8N0Z6 TTC5
3
TTC5 [nucleoplasm]
(R-HSA-6804264)
p-S203-TTC5 [nucleoplasm]
(R-HSA-6804261)
p-S203,S221-TTC5 [nucleoplasm]
(R-HSA-6804259)
0.527
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
6
UniProt:P36507 MAP2K2
12
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
0.527
3
UniProt:P07437 TUBB
3
TUBB [extracellular region]
(R-HSA-380317)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
5
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