Reactome | p-Y599,Y605-EPHA1 [plasma membrane]

p-Y599,Y605-EPHA1 [plasma membrane]

Stable Identifier

R-HSA-3928336

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPH receptors autophosphorylate (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
      - EPH-ephrin mediated repulsion of cells (Homo sapiens)
        
        EPHA binds TIAM1 (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        SFKs phosphorylate VAV2,3 (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        p-EPHs bind VAV2,3 (Homo sapiens)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        NGEF binds EPHA (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        NGEF exchanges GTP for GDP on RHOA (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        SFKs phosphorylate NGEF (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Homo sapiens)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
      - p-EPHs bind SRC,FYN,YES,LYN (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Homo sapiens)
        
        p-EPH:ephrin oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHA:EFNA oligomers [plasma membrane] (Homo sapiens)
        
        p-EPHAs:EFNAs [plasma membrane] (Homo sapiens)
        
        p-EPHAs [plasma membrane] (Homo sapiens)
        
        p-Y599,Y605-EPHA1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21709 EPHA1

Gene Names

EPHA1, EPH, EPHT, EPHT1

Chain

signal peptide:1-25, chain:26-976

Reference Genes

BioGPS Gene:2041 EPHA1

COSMIC (genes):EPHA1 EPHA1

CTD Gene:2041 EPHA1

dbSNP Gene:2041 EPHA1

ENSEMBL:ENSG00000146904 EPHA1

HGNC:3385 EPHA1

KEGG:hsa:2041 EPHA1

Monarch:2041 EPHA1

NCBI Gene:2041 EPHA1

OMIM:179610 EPHA1

UCSC:P21709 EPHA1

Reference Transcript

RefSeq:NM_005232.4 EPHA1

Other Identifiers

1108_s_at

11723373_a_at

11751296_a_at

17063948

2041

205977_PM_s_at

205977_s_at

241482_PM_at

241482_at

3077322

3077323

3077324

3077325

3077326

3077328

3077329

3077330

3077331

3077333

3077334

3077335

3077336

3077337

3077338

3077339

3077340

3077341

3077342

3077343

3077344

3077345

3077346

3077347

3077348

3077349

3077350

3077351

3077352

3077353

3077354

3077355

3077357

3077360

3077361

76621_at

8143575

A_23_P157333

GE62812

GE696096

GO:0001525

GO:0001954

GO:0001968

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005003

GO:0005005

GO:0005515

GO:0005524

GO:0005886

GO:0006468

GO:0006469

GO:0007155

GO:0007166

GO:0007169

GO:0008284

GO:0016020

GO:0016740

GO:0018108

GO:0019901

GO:0030335

GO:0030336

GO:0034446

GO:0043087

GO:0043235

GO:0045766

GO:0046777

GO:0048013

GO:0051496

GO:0060089

GO:0090630

GO:0140096

HMNXSV003006546

Hs.124076.0.A1_3p_at

ILMN_1664265

M18391_s_at

PH_hs_0005023

TC07001971.hg

g4885208_3p_a_at

Participates

as a member of

p-EPHAs [plasma membrane] (Homo sapiens)

Other forms of this molecule

EPHA1 [plasma membrane]

Inferred To

phospho-A0A3Q1MJW2 [plasma membrane] (Bos taurus)

phospho-Q60750 [plasma membrane] (Mus musculus)

phospho-A0A8I3NR10 [plasma membrane] (Canis familiaris)

phospho-Epha1 [plasma membrane] (Rattus norvegicus)

Homologues of p-Y599,Y605-EPHA1 [plasma membrane] (Danio rerio)

phospho-F1NB88 [plasma membrane] (Gallus gallus)

phospho-F1SRW1 [plasma membrane] (Sus scrofa)

phospho-O13146 [plasma membrane] (Danio rerio)

phospho-O61460 [plasma membrane] (Caenorhabditis elegans)

phospho-Q9V4E5 [plasma membrane] (Drosophila melanogaster)

phospho-Q90ZN9 [plasma membrane] (Danio rerio)

phospho-O13148 [plasma membrane] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 599

Coordinate

599

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 605

Coordinate

605

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005223.4

ZINC - World Drugs

EPHA1_HUMAN

Guide to Pharmacology - Targets

1821

OpenTargets

ENSG00000146904

ENSEMBL

ENSP00000275815, ENST00000275815, ENSP00000494931, ENST00000645847

ZINC - FDA approved

EPHA1_HUMAN

ZINC - Substances

EPHA1_HUMAN

ZINC - Biogenic

EPHA1_HUMAN

ZINC target

P21709

PRO

P21709

GlyGen

P21709

PDB

3KKA, 2K1L, 2K1K, 3HIL

ZINC - Investigational

EPHA1_HUMAN

IntEnz

2.7.10.1

HPA

ENSG00000146904-EPHA1

Pharos - Targets

P21709

ZINC - Predictions - Purchasable

EPHA1_HUMAN

HMDB Protein

HMDBP01345

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.615	3
UniProt:Q5JTZ9 AARS2	1	AARS2 [mitochondrial matrix] (R-HSA-379653)	0.527	2
UniProt:Q92538 GBF1	2	GBF1 [cytosol] (R-HSA-6807751) GBF1 [Golgi membrane] (R-HSA-199994)	0.527	2
UniProt:Q15058 KIF14	1	KIF14 [cytosol] (R-HSA-1629804)	0.527	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.527	2
UniProt:Q14012 CAMK1	2	p-T177-CAMK1 [cytosol] (R-HSA-9619377) CAMK1 [cytosol] (R-HSA-9619207)	0.527	2
UniProt:O43592 XPOT	2	XPOT [cytosol] (R-HSA-6783484) XPOT [nucleoplasm] (R-HSA-6783465)	0.527	2
UniProt:P56182 RRP1	1	RRP1 [nucleoplasm] (R-HSA-6792441)	0.527	2
UniProt:O60443 GSDME	18	GSDME(1-270) [cytosol] (R-HSA-9647689) GSDME [cytosol] (R-HSA-9647620) GSDME (271-496) [cytosol] (R-HSA-9647615) GSDME(1-270) E177V [cytosol] (R-HSA-9710403) GSDME(1-270) T196M [cytosol] (R-HSA-9710429) GSDME(1-270) G17D [cytosol] (R-HSA-9710478) GSDME(1-270) E134A [cytosol] (R-HSA-9710410) GSDME(1-270) N24D [cytosol] (R-HSA-9710404) GSDME E210* [cytosol] (R-HSA-9710420) GSDME(1-270) I217N [cytosol] (R-HSA-9710437) GSDME(1-270) W44C [cytosol] (R-HSA-9710470) GSDME(1-270) P212L [cytosol] (R-HSA-9710487) GSDME(1-270) D14Y [cytosol] (R-HSA-9710450) GSDME(1-270) D18V [cytosol] (R-HSA-9710466) GSDME W46* [cytosol] (R-HSA-9711042) GSDME(1-270) I137T [cytosol] (R-HSA-9710473) GSDME(1-270) R48I [cytosol] (R-HSA-9710474) GSDME(1-270) G199E [cytosol] (R-HSA-9710427)	0.527	2
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.527	3
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.527	2
UniProt:Q8WVM7 STAG1	4	STAG1 [nucleoplasm] (R-HSA-163016) STAG1 [chromosome, centromeric region] (R-HSA-2466017) STAG1 [chromosome] (R-HSA-1638773) STAG1 [cytosol] (R-HSA-2484793)	0.527	2
UniProt:Q13144 EIF2B5	1	EIF2B5 [cytosol] (R-HSA-72523)	0.527	2
UniProt:Q6ZT07 TBCD9			0.527	2
UniProt:Q9C0E2 XPO4			0.527	2
UniProt:Q9NSV4 DIAPH3	1	DIAPH3 [cytosol] (R-HSA-5666125)	0.527	2
UniProt:Q96ER3 SAAL1			0.527	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.527	2
UniProt:Q9NR50 EIF2B3	1	EIF2B3 [cytosol] (R-HSA-72525)	0.527	2
UniProt:Q86U38 NOP9			0.527	2
UniProt:O94768 ST17B			0.527	2
UniProt:P50748 KNTC1	1	KNTC1 [cytosol] (R-HSA-376233)	0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:Q8N1S5 S39AB			0.527	2
UniProt:Q7Z4Q2 HEAT3			0.527	2
UniProt:Q02818 NUCB1	2	p-NUCB1 [endoplasmic reticulum lumen] (R-HSA-8957027) NUCB1 [endoplasmic reticulum lumen] (R-HSA-8956751)	0.527	2
UniProt:Q6NUQ1 RINT1	1	RINT1 [cytosol] (R-HSA-6810991)	0.527	2
UniProt:Q9H1Z4 WDR13			0.527	2
UniProt:Q9NRY5 FAM114A2	2	FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802525) FAM114A2(1-327)-BRAF(439-766) fusion [cytosol] (R-HSA-6802321)	0.527	2
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.527	2
UniProt:P49770 EIF2B2	1	EIF2B2 [cytosol] (R-HSA-72519)	0.527	2
UniProt:P42695 NCAPD3	3	p-T1415,S1419-NCAPD3 [nucleoplasm] (R-HSA-2294594) p-T1415-NCAPD3 [nucleoplasm] (R-HSA-2294587) NCAPD3 [nucleoplasm] (R-HSA-1629790)	0.527	2
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.527	2
UniProt:Q96JJ3 ELMO2	1	ELMO2 [cytosol] (R-HSA-372642)	0.527	2
UniProt:P42898 MTHFR	1	MTHFR [cytosol] (R-HSA-200663)	0.527	2
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.519	2
IntAct:EBI-1108795 NPM			0.499	3