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p-Y324,Y329,Y343-EFNB1 [plasma membrane]
Stable Identifier
R-HSA-3928412
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Ephrin-B1, p-EFNB1, phospho-EFNB1
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
GIT1 binds bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
PAK binds RAC and bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
SFKs phosphorylate EFNBs (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y324,Y329,Y343-EFNB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98172 EFNB1
Gene Names
EFNB1, EFL3, EPLG2, LERK2
Chain
signal peptide:1-27, chain:28-346, chain:218-346, chain:260-346
Reference Genes
BioGPS Gene:1947 EFNB1
COSMIC (genes):EFNB1 EFNB1
CTD Gene:1947 EFNB1
dbSNP Gene:1947 EFNB1
ENSEMBL:ENSG00000090776 EFNB1
HGNC:3226 EFNB1
KEGG:hsa:1947 EFNB1
Monarch:1947 EFNB1
NCBI Gene:1947 EFNB1
OMIM:300035 EFNB1
UCSC:P98172 EFNB1
Reference Transcript
RefSeq:NM_004429.4 EFNB1
Other Identifiers
11715912_at
11715913_s_at
11715914_at
17104363
188_at
1947
202711_PM_at
202711_at
2076_s_at
39721_at
3980174
3980175
3980176
3980177
3980181
3980182
3980183
3980184
3980185
3980186
3980187
3980188
8168045
A_14_P102688
A_24_P365807
GE56653
GO:0001755
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005886
GO:0007155
GO:0007267
GO:0007399
GO:0007411
GO:0009880
GO:0009986
GO:0016020
GO:0023052
GO:0030154
GO:0031295
GO:0042098
GO:0042102
GO:0042734
GO:0043226
GO:0045121
GO:0045202
GO:0046875
GO:0048013
GO:0048856
GO:0048870
GO:0070062
GO:0098978
GO:2000785
HMNXSV003021067
ILMN_1654563
PH_hs_0008565
TC0X000362.hg
U09303_at
g4758247_3p_at
Participates
as a member of
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
Other forms of this molecule
EFNB1 [plasma membrane]
Inferred To
phospho-Efnb1 [plasma membrane]
(Mus musculus)
phospho-Efnb1 [plasma membrane]
(Rattus norvegicus)
phospho-efnb1 [plasma membrane]
(Danio rerio)
phospho-efnb1 [plasma membrane]
(Xenopus tropicalis)
phospho-efn-2 [plasma membrane]
(Caenorhabditis elegans)
phospho-Ephrin [plasma membrane]
(Drosophila melanogaster)
phospho-EFNB1 [plasma membrane]
(Bos taurus)
phospho-EFNB1 [plasma membrane]
(Canis familiaris)
phospho-EFNB1 [plasma membrane]
(Gallus gallus)
phospho-EFNB1 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 324
Coordinate
324
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 329
Coordinate
329
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 343
Coordinate
343
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_004420.1
ENSEMBL
ENSP00000204961
,
ENST00000204961
OpenTargets
ENSG00000090776
HPA
ENSG00000090776-EFNB1
PRO
P98172
Pharos - Targets
P98172
GlyGen
P98172
Orphanet
EFNB1
PDB
6THG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.602
12
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.527
3
UniProt:Q6ZMH5 SLC39A5
1
SLC39A5 [plasma membrane]
(R-HSA-442360)
0.527
2
UniProt:P32971 TNFSF8
1
TNFSF8 [plasma membrane]
(R-HSA-5667148)
0.527
3
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