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ARHGEF28 [cytosol]
Stable Identifier
R-HSA-3928474
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p190RhoGEF, Rho guanine nucleotide exchange factor 28, ARG28_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
Recruitment of p190RhoGEF to p-FAK (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N1W1 ARHGEF28
Gene Names
ARHGEF28, KIAA1998, RGNEF
Chain
chain:1-1705
Reference Genes
BioGPS Gene:64283 ARHGEF28
COSMIC (genes):ARHGEF28 ARHGEF28
CTD Gene:64283 ARHGEF28
dbSNP Gene:64283 ARHGEF28
ENSEMBL:ENSG00000214944 ARHGEF28
ENSEMBL_homo_sapiens_GENE:ENSG00000214944.10 ARHGEF28
HGNC:30322 ARHGEF28
KEGG Gene (Homo sapiens):64283 ARHGEF28
Monarch:64283 ARHGEF28
NCBI Gene:64283 ARHGEF28
OMIM:612790 ARHGEF28
UCSC:Q8N1W1 ARHGEF28
Reference Transcript
RefSeq:XM_011543546.1 ARHGEF28
RefSeq:NM_001080479.2 ARHGEF28
RefSeq:NM_001177693.1 ARHGEF28
RefSeq:NM_001244364.1 ARHGEF28
Other Identifiers
11755922_a_at
11755923_x_at
11759746_a_at
11760999_a_at
11763593_a_at
1554003_PM_at
1554003_at
1554004_PM_a_at
1554004_a_at
1560348_PM_at
1560348_at
16986138
219610_PM_at
219610_at
232994_PM_s_at
232994_s_at
2815491
2815498
2815515
2815516
2815521
2815522
2815523
2815530
2815531
2815536
2815540
2815541
2815546
2815547
2815549
2815551
2815552
2815553
2815556
2815559
2815561
2815562
2815563
2815564
2815565
2815567
2815568
2815569
2815570
2815571
2815572
2815573
2815575
2815576
2815581
2815582
2815583
2815586
2815588
2815589
2815593
2815600
2815601
2815602
2815603
61706_at
64283
77588_at
8106210
89322_at
A_14_P120908
A_23_P81298
A_24_P177932
A_32_P213330
A_33_P3367126
GE87968
GO:0000902
GO:0003723
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007010
GO:0016020
GO:0021955
GO:0023052
GO:0030154
GO:0035023
GO:0046872
GO:0048013
GO:0048856
GO:0051056
GO:0060052
GO:0098772
HMNXSV003037876
Hs.33254.1.S1_3p_a_at
Hs2.33254.2.S1_3p_at
Hs2.375089.2.S1_3p_at
ILMN_1652609
ILMN_1807467
ILMN_2281186
PH_hs_0002790
TC05000355.hg
g11967978_3p_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
as an input of
Recruitment of p190RhoGEF to p-FAK (Homo sapiens)
as a component of
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
Inferred To
arhgef28 [cytosol]
(Xenopus tropicalis)
Arhgef28 [cytosol]
(Mus musculus)
Arhgef28 [cytosol]
(Rattus norvegicus)
ARHGEF28 [cytosol]
(Bos taurus)
ARHGEF28 [cytosol]
(Caenorhabditis elegans)
ARHGEF28 [cytosol]
(Canis familiaris)
ARHGEF28 [cytosol]
(Gallus gallus)
ARHGEF28 [cytosol]
(Sus scrofa)
cyst [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001171164.1
,
NP_001073948.2
,
NP_001231293.1
,
XP_011541848.1
OpenTargets
ENSG00000214944
HPA
ENSG00000214944-ARHGEF28
GeneCards
Q8N1W1
Ensembl
ENSG00000214944
,
ENST00000296799
,
ENST00000437974
,
ENST00000513042
,
ENSP00000411459
,
ENSP00000296794
,
ENST00000296794
,
ENSP00000412175
,
ENSP00000441436
,
ENSP00000441913
,
ENSP00000296799
,
ENST00000426542
,
ENST00000545377
PRO
Q8N1W1
Pharos - Targets
Q8N1W1
PDB
6BC0
,
6BC1
HMDB Protein
HMDBP10956
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