Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ARHGEF28 [cytosol]
Stable Identifier
R-HSA-3928474
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p190RhoGEF, Rho guanine nucleotide exchange factor 28, ARG28_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
Recruitment of p190RhoGEF to p-FAK (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF28 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N1W1 ARHGEF28
Gene Names
ARHGEF28, KIAA1998, RGNEF
Chain
chain:1-1705
Reference Genes
BioGPS Gene:64283 ARHGEF28
COSMIC (genes):ARHGEF28 ARHGEF28
CTD Gene:64283 ARHGEF28
dbSNP Gene:64283 ARHGEF28
ENSEMBL:ENSG00000214944 ARHGEF28
HGNC:30322 ARHGEF28
KEGG:hsa:64283 ARHGEF28
Monarch:64283 ARHGEF28
NCBI Gene:64283 ARHGEF28
OMIM:612790 ARHGEF28
UCSC:Q8N1W1 ARHGEF28
Reference Transcript
RefSeq:XM_011543546.1 ARHGEF28
RefSeq:NM_001080479.3 ARHGEF28
RefSeq:NM_001244364.2 ARHGEF28
RefSeq:NM_001177693.2 ARHGEF28
RefSeq:NM_001388078.1 ARHGEF28
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
as an input of
Recruitment of p190RhoGEF to p-FAK (Homo sapiens)
as a component of
EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
Inferred To
arhgef28 [cytosol]
(Xenopus tropicalis)
Arhgef28 [cytosol]
(Mus musculus)
Arhgef28 [cytosol]
(Rattus norvegicus)
ARHGEF28 [cytosol]
(Bos taurus)
ARHGEF28 [cytosol]
(Canis familiaris)
ARHGEF28 [cytosol]
(Gallus gallus)
ARHGEF28 [cytosol]
(Sus scrofa)
rhgf-3 [cytosol]
(Caenorhabditis elegans)
cyst [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001375007.1
,
NP_001073948.2
,
XP_011541848.1
,
NP_001231293.1
,
NP_001171164.1
ENSEMBL
ENSP00000412175
,
ENSP00000441436
,
ENSP00000296799
,
ENSP00000296794
,
ENSP00000411459
,
ENSG00000214944
,
ENST00000296794
,
ENST00000426542
,
ENST00000513042
,
ENST00000296799
,
ENST00000545377
,
ENST00000437974
,
ENSP00000441913
OpenTargets
ENSG00000214944
GeneCards
ARHGEF28
HPA
ENSG00000214944-ARHGEF28
PRO
Q8N1W1
Pharos - Targets
Q8N1W1
HMDB Protein
HMDBP10956
PDB
6BC0
,
6BC1
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text