SFKs phosphorylate EFNBs

Stable Identifier
R-HSA-3928580
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SFKs phosphorylate EFNBs
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The Src-family kinases (SFKs) SRC and FYN, colocalised with ephrinBs (EFNBs) at the membrane, are required for EFNB phosphorylation. The cytoplasmic domains of all three EFNBs consist of five conserved tyrosine residues of which three undergo phosphorylation. Electrospray tandem mass spectrometry and site-directed mutagenesis identified tyrosines 312, 317, and 331 (human 324, 329 and 343) of EFNB1 as phosphorylation sites (Kalo et al. 2001, Palmer et al. 2002).
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as an event of
Catalyst Activity

protein tyrosine kinase activity of EPHBs:EFNBs:SRC,FYN [plasma membrane]

Physical Entity
EPHBs:EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Sfks phosphorylate EfnB1 (Gallus gallus)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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