Reactome | EPH:EFN dimers tetramerise

EPH:EFN dimers tetramerise

Stable Identifier

R-HSA-3928597

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Two class A or B EPH:EFN complexes dimerise to form a 2:2 tetramer, forming a ring-like structure, in which each receptor interacts with two ligands and each ligand with two receptors (Himanen et al. 2001). In the tetrameric form the molecules are arranged so that the C-termini of both ligands are located on one side, and the C-termini of the receptors on the other (Himanen & Nikolov 2003).

Literature References

PubMed ID	Title	Journal	Year
12495863	Eph signaling: a structural view Himanen, JP, Nikolov, DB	Trends Neurosci.	2003
11780069	Crystal structure of an Eph receptor-ephrin complex Lackmann, M, Henkemeyer, M, Himanen, JP, Rajashankar, KR, Nikolov, DB, Cowan, CA	Nature	2001