p-EPHs bind VAV2,3

Stable Identifier
R-HSA-3928607
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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p-EPHs bind VAV2,3
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The alternate method required for the initial EPH receptor:ephrin (EPH:EFN) adhesion into repulsion is by RAC-dependent endocytosis, an atypical endocytic mechanism by which the EPH:EFN complex and surrounding plasma membrane are internalized into one cell. Proto-oncogene vavs (VAVs) provide a molecular link between activated EPHs and RAC-dependent endocytosis. Upon the activation of EPH receptor, VAV proteins are recruited to the intracellular domain of EPHs and become transiently activated. Cowan et al. showed that VAV2 interacts with either EPHA4 or EPHB2, indicating that VAV can bind to either EPHA or EPHB subclass receptors. Autophosphorylated juxta-membrane tyrosines (Y596 and Y602 of human EPHA4) provide docking sites for VAV proteins (Cowan et al. 2007).
Literature References
PubMed ID Title Journal Year
15848800 Vav family GEFs link activated Ephs to endocytosis and axon guidance

Sahin, M, Greenberg, ME, Gao, S, Griffith, EC, Lin, MZ, Shao, YR, Shamah, SM, Cowan, CW, Brugge, JS, Greer, PL

Neuron 2005
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Orthologous Events
p-EPHs bind VAV2,3 (Bos taurus)
p-EPHs bind VAV2,3 (Caenorhabditis elegans)
p-EPHs bind VAV2,3 (Canis familiaris)
p-EPHs bind VAV2,3 (Drosophila melanogaster)
p-EPHs bind VAV2,3 (Gallus gallus)
p-EPHs bind VAV2,3 (Mus musculus)
p-EPHs bind VAV2,3 (Rattus norvegicus)
p-EPHs bind VAV2,3 (Sus scrofa)
p-EPHs bind VAV2,3 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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