PTK2 autophosphorylates at Y397

Stable Identifier
R-HSA-3928610
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Focal adhesion kinase 1 (PTK2, FAK, FAK1) activation plays a critical role in EPHB receptor signaling in dendritic spines. PTK2 has six tyrosine phosphorylation sites, with tyrosine 397 being the main auto-phosphorylation site present upstream of the kinase domain (Schaller et al. 1994). Activation of EPHB receptors induces long-lasting phosphorylation of PTK2 on tyrosine 397 (Shi et al. 2009). This phosphorylated tyrosine then creates a binding site for other signaling proteins that link PTK2 to downstream signaling pathways and actin cytoskeleton.

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Catalyst Activity

protein tyrosine kinase activity of EFNBs:p-EPHBs:PTK2 [plasma membrane]

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