Reactome | EFNB:GRB4 binds GIT1

EFNB:GRB4 binds GIT1

Stable Identifier

R-HSA-3928614

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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G-protein-coupled receptor kinase-interacting protein 1 (GIT1) is enriched in both presynaptic and postsynaptic terminals and after phosphorylation is targeted to the synapse by binding to cytoplasmic protein GRB4 (NCK2 aka GRB4). GRB4 binds by its SH2 domain to Tyr392 (Human Tyr383) in the synaptic localization domain (SLD) of GIT1. GIT1 acts as an adapter protein by providing docking site for beta-PIX (PAK interacting exchange factor) and serves to localize Rac activity (Segura et al. 2007, Zhang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
17310244	Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation Acker-Palmer, A, Essmann, CL, Weinges, S, Segura, I	Nat. Neurosci.	2007
12695502	Synapse formation is regulated by the signaling adaptor GIT1 Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H	J. Cell Biol.	2003