EFNBs bind SFKs

Stable Identifier
R-HSA-3928615
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EFNBs bind SFKs
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Src-family kinases (SFKs) are required for ephrinB (EFNB)-mediated axon guidance and angiogenic responses in endothelial cells. Following interaction with their cognate EPHB receptors and formation of circular tetramers and higher order clusters, EFNBs recruit SFKs and become tyrosine phosphorylated on the cytoplasmic tail. SFK recruitment and activation represents one of the first events in EFNB reverse signaling (Palmer et al. 2002).
Literature References
PubMed ID Title Journal Year
11983165 EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase

Klein, R, Zimmer, M, Deutsch, U, Eulenburg, V, Porthin, A, Palmer, A, Heumann, R, Erdmann, KS

Mol. Cell 2002
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Orthologous Events
EFNBs bind SFKs (Bos taurus)
EFNBs bind SFKs (Caenorhabditis elegans)
EFNBs bind SFKs (Canis familiaris)
EFNBs bind SFKs (Danio rerio)
EFNBs bind SFKs (Drosophila melanogaster)
EFNBs bind SFKs (Gallus gallus)
EFNBs bind SFKs (Mus musculus)
EFNBs bind SFKs (Rattus norvegicus)
EFNBs bind SFKs (Sus scrofa)
EFNBs bind SFKs (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
Cite Us!