EPHB2 binds KALRN

Stable Identifier
R-HSA-3928617
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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EPHB2 binds KALRN
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Penzes et al. showed that the Kalirin-Rac1-PAK pathway is another signaling cascade downstream of EPHB2 that leads to dendritic spine maturation (Penzes et al. 2003). Kalirin (KALRN) is a Rac-GEF expressed postnatally in neurons and localised to the postsynaptic densities at excitatory synapses, where it participates in the formation and maintenance of dendritic spines. In young hippocampal pyramidal neurons, KALRN links trans-synaptic signaling through ephrinB (EFNB) and EPHB receptors to spine formation and maturation. Upon EFNB activation, KALRN binds EPHB2 and translocates to the postsynaptic membrane.
Literature References
PubMed ID Title Journal Year
12546821 Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

Penzes, P, Eipper, BA, Schiller, MR, Huganir, RL, Chernoff, J, Beeser, A, Mains, RE

Neuron 2003
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Orthologous Events
EPHB2 binds KALRN (Caenorhabditis elegans)
EPHB2 binds KALRN (Canis familiaris)
EPHB2 binds KALRN (Drosophila melanogaster)
EPHB2 binds KALRN (Gallus gallus)
EPHB2 binds KALRN (Mus musculus)
EPHB2 binds KALRN (Rattus norvegicus)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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