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EPHBs bind NMDARs
Stable Identifier
R-HSA-3928623
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHBs bind NMDARs (Homo sapiens)
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EPHBs are involved in spine synapse formation and also for the recruitment and clustering of glutamate receptors to synapses. At the time of synaptogenesis, EPHBs are localized to the postsynaptic region of excitatory synapses. These postsynaptic EPHBs, upon activation by presynaptic ephrinBs (EFNBs), directly interact with ionotropic glutamate receptor, NR1 and NR2B (NMDAR1and 2B aka GRIN1and 2B). The interaction between EPHB and NMDARs is mediated by the extracellular domains of these two proteins. This interaction promotes clustering of NMDARs at synaptic locations and leads to the formation of functional presynaptic release sites. Activated EPHBs function as tyrosine kinases and may also indirectly potentiate NMDAR-mediated calcium influx (Dalva et al. 2000, Takasu et al. 2002).
Participants
Input
EFNBs:p-EPHBs:SFKs [plasma membrane]
(Homo sapiens)
Glu:NMDAR:Gly [plasma membrane]
(Homo sapiens)
Output
EFNBs:p-EPHBs:SFKs:Glu:NMDAR:Gly [plasma membrane]
(Homo sapiens)
Entity On Other Cell
EFNBs [plasma membrane]
(Homo sapiens)
Participates
as an event of
EPHB-mediated forward signaling (Homo sapiens)
Inferred From
Ephb2 bind Nmdar (Mus musculus)
Authored
Garapati, P V (2013-07-23)
Reviewed
Ip, NY (2014-05-19)
Created
Garapati, P V (2013-07-22)
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