GIT1 binds bPIX

Stable Identifier
R-HSA-3928631
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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GIT1 binds bPIX
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p-21-activated kinase (PAK) interacting exchange factor (beta-PIX, bPIX aka ARHGEF7) is a Rac guanine nucleotide exchange factor that acts downstream of GIT1 to affect spine morphology and synapse formation. Endogenous bPIX is present in hippocampal neurons and is targeted to the synapses by binding to GIT1. bPIX serves as an exchange factor for Rac and a binding protein for a Rac effector, PAK (Zhang et al. 2003).
Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H

J. Cell Biol. 2003
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Orthologous Events
GIT1 binds bPIX (Bos taurus)
GIT1 binds bPIX (Caenorhabditis elegans)
GIT1 binds bPIX (Canis familiaris)
GIT1 binds bPIX (Drosophila melanogaster)
GIT1 binds bPIX (Gallus gallus)
GIT1 binds bPIX (Mus musculus)
GIT1 binds bPIX (Rattus norvegicus)
GIT1 binds bPIX (Sus scrofa)
GIT1 binds bPIX (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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