bPIX exchanges GTP for GDP on RAC, activating it

Stable Identifier
R-HSA-3928633
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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bPIX exchanges GTP for GDP on RAC, activating it
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p-21-activated kinase (PAK) interacting exchange factor (beta-PIX, bPIX aka ARHGEF7) a Rac GEF localised at the dendritic spines, activates Rac by exchanging GDP for GTP.
Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H

J. Cell Biol. 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane]

Physical Entity
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
bPIX exchanges GTP for GDP on RAC, activating it (Bos taurus)
bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)
bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)
bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)
bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)
bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)
bPIX exchanges GTP for GDP on RAC, activating it (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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