bPIX exchanges GTP for GDP on RAC, activating it

Stable Identifier
R-HSA-3928633
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
bPIX exchanges GTP for GDP on RAC, activating it
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p-21-activated kinase (PAK) interacting exchange factor (beta-PIX, bPIX aka ARHGEF7) a Rac GEF localised at the dendritic spines, activates Rac by exchanging GDP for GTP.
Literature References
PubMed ID Title Journal Year
12695502 Synapse formation is regulated by the signaling adaptor GIT1

Zhang, H, Webb, DJ, Asmussen, H, Horwitz, AF

J. Cell Biol. 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane]

Physical Entity
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
bPIX exchanges GTP for GDP on RAC, activating it (Caenorhabditis elegans)
bPIX exchanges GTP for GDP on RAC, activating it (Canis familiaris)
bPIX exchanges GTP for GDP on RAC, activating it (Danio rerio)
bPIX exchanges GTP for GDP on RAC, activating it (Drosophila melanogaster)
bPIX exchanges GTP for GDP on RAC, activating it (Gallus gallus)
bPIX exchanges GTP for GDP on RAC, activating it (Mus musculus)
bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
bPIX exchanges GTP for GDP on RAC, activating it (Sus scrofa)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
Cite Us!