Reactome | PAKs phosphorylate MLC

PAKs phosphorylate MLC

Stable Identifier

R-HSA-3928640

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Myosin II regulatory light chain (MLC) acts downstream of serine/threonine-protein kinase PAK (PAK) to mediate its effect on spine morphogenesis and excitatory synapse formation. PAK directly phosphorylates MLC on serine 19. MLC phosphorylation could promote dendritic spine morphogenesis by stabilizing the actin network at this site (Zhang et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
10047984	Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK) Goeckeler, ZM, Masaracchia, RA, Wysolmerski, RB, Chew, TL	J. Muscle Res. Cell. Motil.	1998
15800193	A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H, Niu, S	J. Neurosci.	2005