PAK binds RAC and bPIX

Stable Identifier
R-HSA-3928641
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PAK binds RAC and bPIX
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Serine/threonine-protein kinases PAK1, 2 and 3 (PAK1,2,3) serve as downstream effectors of RACs in regulating spine and synapse formation. Once activated, Ras-related C3 botulinum toxin substrate 1 (RAC1) binds to a variety of downstream effector proteins. Among the most well characterized effectors are PAKs. In addition to binding active RAC, PAKs also directly bind p-21-activated kinase (PAK) interacting exchange factor (beta-PIX, bPIX aka ARHGEF7) (Zhang et al. 2005).
Literature References
PubMed ID Title Journal Year
15800193 A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC

Webb, DJ, Zhang, H, Horwitz, AF, Asmussen, H, Niu, S

J. Neurosci. 2005
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Orthologous Events
PAK binds RAC and bPIX (Bos taurus)
PAK binds RAC and bPIX (Caenorhabditis elegans)
PAK binds RAC and bPIX (Canis familiaris)
PAK binds RAC and bPIX (Drosophila melanogaster)
PAK binds RAC and bPIX (Gallus gallus)
PAK binds RAC and bPIX (Mus musculus)
PAK binds RAC and bPIX (Rattus norvegicus)
PAK binds RAC and bPIX (Sus scrofa)
PAK binds RAC and bPIX (Xenopus tropicalis)
Authored
Garapati, P V  (2013-07-23)
Reviewed
Ip, NY  (2014-05-19)
Created
Garapati, P V  (2013-07-22)
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