Reactome | RHOA:GTP:Mg2+ binds ROCK1,ROCK2

RHOA:GTP:Mg2+ binds ROCK1,ROCK2

Stable Identifier

R-HSA-3928647

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000). Heat-shock protein of 90 kDa (HSP90) recruited to VEGFR2 initiates the activation of Rho-dependent kinase (ROCK) (Le Boeuf et al. 2004, 2006).

Literature References

PubMed ID	Title	Journal	Year
21445309	Crystal structure of a coiled-coil domain from human ROCK I Li, Y, Marto, JA, Song, HK, Gould, CJ, Ficarro, SB, Tu, D, Eck, MJ, Goode, BL, Toms, AV	PLoS ONE	2011
8617235	The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase Saito, Y, Fujita, A, Narumiya, S, Okawa, K, Iwamatsu, A, Morii, N, Fujisawa, K, Kakizuka, A, Ishizaki, T, Watanabe, N, Maekawa, M	EMBO J	1996