Reactome | VANGL2 [plasma membrane]

VANGL2 [plasma membrane]

Stable Identifier

R-HSA-3965373

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

KIAA1215, STB1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9ULK5 VANGL2

Gene Names

VANGL2, KIAA1215, STB1

Chain

chain:1-521

Reference Genes

BioGPS Gene:57216 VANGL2

COSMIC (genes):VANGL2 VANGL2

CTD Gene:57216 VANGL2

dbSNP Gene:57216 VANGL2

ENSEMBL:ENSG00000162738 VANGL2

HGNC:15511 VANGL2

KEGG:hsa:57216 VANGL2

Monarch:57216 VANGL2

NCBI Gene:57216 VANGL2

OMIM:600533 VANGL2

UCSC:Q9ULK5 VANGL2

Reference Transcript

Other Identifiers

11721740_at

11721741_at

16672635

226029_PM_at

226029_at

2363141

2363142

2363143

2363144

2363149

2363150

2363151

2363152

2363154

2363156

2363157

2363158

2363159

2363160

2363162

57216

7906602

90296_at

A_33_P3282005

GE53831

GO:0001725

GO:0001736

GO:0001843

GO:0001942

GO:0001947

GO:0003149

GO:0003150

GO:0005515

GO:0005886

GO:0005911

GO:0006790

GO:0007163

GO:0007266

GO:0007275

GO:0009952

GO:0015012

GO:0016020

GO:0016323

GO:0016324

GO:0016328

GO:0022007

GO:0030111

GO:0030134

GO:0031410

GO:0032835

GO:0032956

GO:0035019

GO:0035567

GO:0035787

GO:0036342

GO:0036514

GO:0036515

GO:0042060

GO:0044782

GO:0045176

GO:0045197

GO:0048103

GO:0048105

GO:0048546

GO:0048856

GO:0048870

GO:0060028

GO:0060029

GO:0060071

GO:0060119

GO:0060122

GO:0060187

GO:0060488

GO:0060489

GO:0060490

GO:0060993

GO:0071944

GO:0090102

GO:0090103

GO:0090175

GO:0090177

GO:0090651

GO:0098839

GO:0098978

GO:1901135

GO:1905515

GO:1905806

HMNXSV003026171

Hs.137507.0.S1_3p_at

ILMN_1715647

PH_hs_0008298

TC01001369.hg

Participates

as a candidate of

as a component of

as an input of

Other forms of this molecule

pS5,S82,S84-VANGL2 [plasma membrane]

Inferred To

vangl2 [plasma membrane] (Danio rerio)

vangl2 [plasma membrane] (Xenopus tropicalis)

VANGL2 [plasma membrane] (Bos taurus)

VANGL2 [plasma membrane] (Canis familiaris)

VANGL2 [plasma membrane] (Gallus gallus)

VANGL2 [plasma membrane] (Sus scrofa)

Vangl2 [plasma membrane] (Mus musculus)

Vangl2 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_005245414.1, XP_054193781.1, XP_054193780.1, NP_065068.1, XP_011508106.1, XP_047281976.1

OpenTargets

ENSG00000162738

ENSEMBL

ENST00000368061, ENSP00000357040, ENSG00000162738

HPA

ENSG00000162738-VANGL2

GeneCards

VANGL2

PRO

Q9ULK5

Pharos - Targets

Q9ULK5

Orphanet

VANGL2

PDB

9JK7, 7R2T, 9JKA, 7R2M, 6XA6, 6XA8, 6XA7

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.643	3
UniProt:Q8NFN8 GP156			0.643	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.564	2
UniProt:Q9H4G0 EPB41L1	2	EPB41L1 [cytosol] (R-HSA-392241) EPB41L1 [plasma membrane] (R-HSA-416333)	0.527	2
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.527	2
UniProt:P21589 NT5E	1	NT5E [plasma membrane] (R-HSA-49191)	0.527	2
UniProt:Q9NQ34 TMM9B			0.527	2
UniProt:Q8WWF5 ZNRF4			0.527	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.527	2
UniProt:Q496J9 SV2C	2	SV2C [synaptic vesicle membrane] (R-HSA-5244432) SV2C [plasma membrane] (R-HSA-5216015)	0.527	2
UniProt:Q9H8J5 MANS1			0.527	2
UniProt:P22460 KCNA5	1	KCNA5 [plasma membrane] (R-HSA-977472)	0.527	2
UniProt:Q8TBK6 ZCH10			0.527	2
UniProt:Q9BQ31 KCNS3	1	KCNS3 [plasma membrane] (R-HSA-381709)	0.527	2
UniProt:Q96JJ6 JPH4			0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.527	2
UniProt:O43291 SPINT2	1	SPINT2 [extracellular region] (R-HSA-6800233)	0.527	2
UniProt:Q7Z4V5 HDGR2			0.527	3
UniProt:P33151 CDH5	2	p-S665-VE-cadherin [plasma membrane] (R-HSA-5357435) VE-cadherin [plasma membrane] (R-HSA-418992)	0.527	2
UniProt:P26045 PTPN3	3	PTPN3 [cytosol] (R-HSA-8867650) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317)	0.499	2

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