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PLXNA1 [plasma membrane]
Stable Identifier
R-HSA-396932
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Plexin-A1, PLXA1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
CRMPs in Sema3A signaling (Homo sapiens)
Activation of Fyn (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Phosphorylation of CRMPs by Cdk5 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:Cdk5:p53:p-CRMP tetramers [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:Cdk5:p35:p-CRMP tetramers [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Recruitment and activation of Cdk5 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 [plasma membrane] (Homo sapiens)
NRP1:PlexinA1-4:FYN:pCdk5:p53 [plasma membrane] (Homo sapiens)
PlexinA1-4:FYN:pCdk5:p35 [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA6D binds to PLXNA1:TREM2:DAP12 (Homo sapiens)
PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
SEMA6D:PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Phosphorylation of Plexin-A (Homo sapiens)
Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Homo sapiens)
NRP1:Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Plexin-A1-4 binds NRP1 (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:Plexin A:Fyn [plasma membrane] (Homo sapiens)
NRP1:Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD binds effectors at the plasma membrane (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
RHOD:GTP:RHOD plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds effectors (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
RND1:GTP:RND1 effectors [plasma membrane] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
PLXNA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UIW2 PLXNA1
Gene Names
PLXNA1, NOV, PLXN1
Chain
signal peptide:1-26, chain:27-1896
Reference Genes
BioGPS Gene:5361 PLXNA1
COSMIC (genes):PLXNA1 PLXNA1
CTD Gene:5361 PLXNA1
dbSNP Gene:5361 PLXNA1
ENSEMBL:ENSG00000114554 PLXNA1
HGNC:9099 PLXNA1
KEGG:hsa:5361 PLXNA1
Monarch:5361 PLXNA1
NCBI Gene:5361 PLXNA1
OMIM:601055 PLXNA1
UCSC:Q9UIW2 PLXNA1
Reference Transcript
RefSeq:NM_032242.3 PLXNA1
Other Identifiers
11719639_a_at
11719640_a_at
1558140_PM_at
1558140_at
16945051
221537_PM_at
221537_at
221538_PM_s_at
221538_s_at
2640580
2640581
2640582
2640583
2640584
2640585
2640587
2640600
2640601
2640602
2640603
2640604
2640606
2640607
2640608
2640609
2640610
2640611
2640612
2640613
2640614
2640615
2640616
2640617
2640619
2640621
2640623
2640624
2640625
2640627
2640628
2640630
2640632
2640633
2640635
2640636
2640637
2640638
2640639
2640642
2640643
2640646
2640647
2640648
2640649
2640651
2640652
46601_at
5361
8082314
A_14_P138535
A_23_P57667
A_23_P69068
GE87012
GO:0002116
GO:0002291
GO:0002376
GO:0005515
GO:0005654
GO:0005829
GO:0005886
GO:0007162
GO:0008360
GO:0014910
GO:0016020
GO:0017154
GO:0021628
GO:0021828
GO:0030334
GO:0043226
GO:0045202
GO:0048870
GO:0050772
GO:0060089
GO:0060666
GO:0070062
GO:0071526
GO:0097485
GO:0098978
GO:1990138
HMNXSV003001330
Hs.322844.0.S1_3p_at
Hs.322844.0.S1_3p_x_at
Hs2.398130.1.S1_3p_s_at
ILMN_1791569
PH_hs_0026963
PH_hs_0033303
PH_hs_0041172
TC03000661.hg
TC03002520.hg
g12052849_3p_a_at
Participates
as a member of
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
Plexin-A1-4 [plasma membrane] (Homo sapiens)
as a component of
PLXNA1:TREM2:DAP12 [plasma membrane] (Homo sapiens)
Sema3A:Plexin-A1:Neuropilin-1:LIMK-1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y-PLXNA1 [plasma membrane]
Inferred To
plxna1b [plasma membrane]
(Danio rerio)
PLXNA1 [plasma membrane]
(Bos taurus)
PLXNA1 [plasma membrane]
(Canis familiaris)
PLXNA1 [plasma membrane]
(Gallus gallus)
PLXNA1 [plasma membrane]
(Sus scrofa)
PlexA [plasma membrane]
(Drosophila melanogaster)
plx-1 [plasma membrane]
(Caenorhabditis elegans)
Plxna1 [plasma membrane]
(Mus musculus)
Plxna1 [plasma membrane]
(Rattus norvegicus)
plxna1 [plasma membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000393409
,
ENSP00000377061
,
ENSG00000114554
OpenTargets
ENSG00000114554
GeneCards
PLXNA1
HPA
ENSG00000114554-PLXNA1
PRO
Q9UIW2
Pharos - Targets
Q9UIW2
GlyGen
Q9UIW2
Orphanet
PLXNA1
PDB
7Y4P
,
7Y4Q
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59665 DEFA1
9
DEFA1(1-94) [Golgi lumen]
(R-HSA-1467215)
DEFA1(20-94) [Golgi lumen]
(R-HSA-1467282)
DEFA1(66-94) [Golgi lumen]
(R-HSA-975663)
DEFA1(20-65) [Golgi lumen]
(R-HSA-8864970)
DEFA1(66-94) [extracellular region]
(R-HSA-1461998)
DEFA1(66-94) [azurophil granule lumen]
(R-HSA-1470038)
DEFA1(65-94) [extracellular region]
(R-HSA-1462022)
omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region]
(R-HSA-1972397)
DEFA1(65-94) [azurophil granule lumen]
(R-HSA-1470053)
0.527
2
UniProt:Q01523 DEFA5
5
DEFA5(1-94) [Golgi lumen]
(R-HSA-1467267)
DEFA5(20-94) [Golgi lumen]
(R-HSA-1467208)
DEFA5(20-94) [secretory granule lumen]
(R-HSA-1471358)
DEFA5(20-94) [extracellular region]
(R-HSA-1471344)
DEFA5(?-94) [extracellular region]
(R-HSA-1462017)
0.527
2
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