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Thrombin-activated PARs binds G-protein Gq
Stable Identifier
R-HSA-396996
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Thrombin-activated PARs binds G-protein Gq (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Thrombin signalling through PARs is mediated in part through the Gq family of G-proteins. Gq knockout mice have defective platelet responses to thrombin (as well as to ADP and thromboxane).
Literature References
PubMed ID
Title
Journal
Year
8982657
Direct evidence for two distinct G proteins coupling with thrombin receptors in human neuroblastoma SH-EP cells
Tanaka, K
,
Shimizu, N
,
Ogino, Y
Eur J Pharmacol
1996
Participants
Input
Heterotrimeric G-protein Gq/11 (inactive) [plasma membrane]
(Homo sapiens)
Thrombin-activated PARs [plasma membrane]
(Homo sapiens)
Output
Thrombin-activated PARs:Gq (inactive) [plasma membrane]
(Homo sapiens)
Participates
as an event of
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Orthologous Events
Thrombin-activated PARs binds G-protein Gq (Bos taurus)
Thrombin-activated PARs binds G-protein Gq (Caenorhabditis elegans)
Thrombin-activated PARs binds G-protein Gq (Canis familiaris)
Thrombin-activated PARs binds G-protein Gq (Gallus gallus)
Thrombin-activated PARs binds G-protein Gq (Mus musculus)
Thrombin-activated PARs binds G-protein Gq (Sus scrofa)
Thrombin-activated PARs binds G-protein Gq (Xenopus tropicalis)
Authored
Akkerman, JW (2009-06-03)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-03-11)
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