Reactome | LIMK1 [cytosol]

LIMK1 [cytosol]

Stable Identifier

R-HSA-397785

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

LIM domain kinase 1 (LIMK-1) , LIMK1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P23528 CFL1

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PAKs (Homo sapiens)
        
        PAK1 phosphorylates LIMK1 (Homo sapiens)
        
        LIMK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P53667 LIMK1

Gene Names

LIMK1, LIMK

Chain

chain:1-647

Reference Genes

BioGPS Gene:3984 LIMK1

COSMIC (genes):LIMK1 LIMK1

CTD Gene:3984 LIMK1

dbSNP Gene:3984 LIMK1

ENSEMBL:ENSG00000106683 LIMK1

HGNC:6613 LIMK1

KEGG:hsa:3984 LIMK1

Monarch:3984 LIMK1

NCBI Gene:3984 LIMK1

OMIM:601329 LIMK1

UCSC:P53667 LIMK1

Reference Transcript

Other Identifiers

1015_s_at

11724614_at

11724615_at

11747621_a_at

17047045

204357_PM_s_at

204357_s_at

208372_PM_s_at

208372_s_at

3008109

3008110

3008111

3008113

3008116

3008117

3008118

3008119

3008122

3008123

3008124

3008125

3008126

3008127

3008128

3008129

3008130

3008131

3008132

3008133

3008134

3008135

3008136

3008137

3008138

3008140

3008141

3008142

3008143

3984

8133413

A_14_P110764

A_23_P215461

GE59301

GO:0001673

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0006468

GO:0007010

GO:0007165

GO:0007266

GO:0007399

GO:0016020

GO:0016607

GO:0016740

GO:0030027

GO:0030036

GO:0031072

GO:0032233

GO:0038096

GO:0042995

GO:0043005

GO:0043149

GO:0043226

GO:0045773

GO:0046872

GO:0048675

GO:0048856

GO:0051444

GO:0051496

GO:0098794

GO:0098978

GO:0106310

GO:0140096

ILMN_1698649

ILMN_1797362

PH_hs_0002901

PH_hs_0035415

TC07000450.hg

U62293_rna1_s_at

g4587498_3p_a_at

g8051616_3p_a_at

Participates

as an input of

as a member of

LIM Kinases [cytosol] (Homo sapiens)

as a component of

Sema3A:Plexin-A1:Neuropilin-1:LIMK-1 [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-T508-LIMK1 [cytosol]

p-S,T508-LIMK1 [cytosol]

Inferred To

LIMK1 [cytosol] (Bos taurus)

LIMK1 [cytosol] (Canis familiaris)

LIMK1 [cytosol] (Danio rerio)

LIMK1 [cytosol] (Dictyostelium discoideum)

LIMK1 [cytosol] (Drosophila melanogaster)

LIMK1 [cytosol] (Gallus gallus)

LIMK1 [cytosol] (Mus musculus)

LIMK1 [cytosol] (Rattus norvegicus)

LIMK1 [cytosol] (Sus scrofa)

LIMK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001191355.1, NP_002305.1

ZINC - World Drugs

LIMK1_HUMAN

Guide to Pharmacology - Targets

2054

OpenTargets

ENSG00000106683

ENSEMBL

ENSP00000414606, ENSP00000336740, ENST00000336180, ENST00000435201, ENST00000538333, ENSP00000444452

ZINC - FDA approved

LIMK1_HUMAN

ZINC - Substances

LIMK1_HUMAN

ZINC - Biogenic

LIMK1_HUMAN

ZINC target

P53667

PRO

P53667

PDB

3S95, 7ATS, 5HVJ, 5NXC, 7B8W, 7ATU, 5L6W, 5HVK, 8AAU, 6WLY

ZINC - Investigational

LIMK1_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000106683-LIMK1

Pharos - Targets

P53667

Orphanet

LIMK1

ZINC - Predictions - Purchasable

LIMK1_HUMAN

HMDB Protein

HMDBP01538

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.722	3
UniProt:Q8WYL5 SSH1			0.676	6
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.619	5
UniProt:P57058 HUNK			0.573	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.558	2
UniProt:Q8WYQ4-2 C22ORF15			0.556	3
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.556	5
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:P46013 KI67			0.527	2
UniProt:P63319	1	PRKCG [cytosol] (R-RNO-58204)	0.524	3
UniProt:P29067	3	Arrb2 [endocytic vesicle membrane] (R-RNO-9910881) Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.524	2
UniProt:P29066	6	ARRB1 [cytoplasmic vesicle membrane] (R-RNO-351187) ARRB1 [Golgi membrane] (R-RNO-350831) ARRB1 [lysosomal membrane] (R-RNO-432701) ARRB1 [endocytic vesicle membrane] (R-RNO-9910882) PolyUb-ARRB1 [cytosol] (R-RNO-6783186) ARRB1 [cytosol] (R-RNO-264470)	0.524	2
UniProt:P50281 MMP14	4	MMP14 [plasma membrane] (R-HSA-1442472) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [Golgi membrane] (R-HSA-9858808)	0.463	4

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