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p-T508-LIMK1 [cytosol]
Stable Identifier
R-HSA-399816
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:P23528 CFL1
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Dimerization of LIMK1 by Hsp90 (Homo sapiens)
p-T508-LIMK1 [cytosol] (Homo sapiens)
Phosphorylation of LIMK-1 by PAK (Homo sapiens)
p-T508-LIMK1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Dimerization of LIMK1 by Hsp90 (Homo sapiens)
p-T508-LIMK1 [cytosol] (Homo sapiens)
PAK1 phosphorylates LIMK1 (Homo sapiens)
p-T508-LIMK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
PAK1 phosphorylates LIMK1 (Homo sapiens)
p-T508-LIMK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53667 LIMK1
Gene Names
LIMK1, LIMK
Chain
chain:1-647
Reference Genes
BioGPS Gene:3984 LIMK1
COSMIC (genes):LIMK1 LIMK1
CTD Gene:3984 LIMK1
dbSNP Gene:3984 LIMK1
ENSEMBL:ENSG00000106683 LIMK1
ENSEMBL_homo_sapiens_GENE:ENSG00000106683.15 LIMK1
HGNC:6613 LIMK1
KEGG Gene (Homo sapiens):3984 LIMK1
Monarch:3984 LIMK1
NCBI Gene:3984 LIMK1
OMIM:601329 LIMK1
UCSC:P53667 LIMK1
Reference Transcript
RefSeq:NM_002314.3 LIMK1
RefSeq:NM_001204426.1 LIMK1
Other Identifiers
1015_s_at
11724614_at
11724615_at
11747621_a_at
17047045
204357_PM_s_at
204357_s_at
208372_s_at
3008109
3008110
3008111
3008113
3008116
3008117
3008118
3008119
3008122
3008123
3008125
3008126
3008127
3008128
3008129
3008130
3008131
3008134
3008135
3008138
3008140
3008141
3008142
3008143
3984
8133413
A_23_P215461
GE59301
GO:0000166
GO:0001673
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005925
GO:0006468
GO:0007010
GO:0007165
GO:0007266
GO:0007399
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0023052
GO:0030027
GO:0030036
GO:0030154
GO:0031072
GO:0032233
GO:0036211
GO:0038096
GO:0042995
GO:0043005
GO:0043149
GO:0043226
GO:0045773
GO:0046872
GO:0048675
GO:0048856
GO:0051444
GO:0051496
GO:0106310
GO:0140096
ILMN_1698649
ILMN_1797362
PH_hs_0002901
PH_hs_0035415
TC07000450.hg
U62293_rna1_s_at
g4587498_3p_a_at
g8051616_3p_a_at
Participates
as a member of
p-LIMK [cytosol] (Homo sapiens)
as an output of
Phosphorylation of LIMK-1 by PAK (Homo sapiens)
PAK1 phosphorylates LIMK1 (Homo sapiens)
as an input of
Dimerization of LIMK1 by Hsp90 (Homo sapiens)
as a component of
pLIMK dimer:HSP-90 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S,T508-LIMK1 [cytosol]
LIMK1 [cytosol]
Inferred To
phospho-p-T508-LIMK1 [cytosol]
(Bos taurus)
phospho-p-T508-LIMK1 [cytosol]
(Danio rerio)
phospho-p-T508-LIMK1 [cytosol]
(Dictyostelium discoideum)
phospho-p-T508-LIMK1 [cytosol]
(Drosophila melanogaster)
phospho-p-T508-LIMK1 [cytosol]
(Gallus gallus)
phospho-p-T508-LIMK1 [cytosol]
(Mus musculus)
phospho-p-T508-LIMK1 [cytosol]
(Rattus norvegicus)
phospho-p-T508-LIMK1 [cytosol]
(Sus scrofa)
phospho-p-T508-LIMK1 [cytosol]
(Xenopus tropicalis)
phospho-LIMK1 [cytosol]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-threonine at 508
Coordinate
508
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001191355.1
,
NP_002305.1
ZINC - World Drugs
LIMK1_HUMAN
Guide to Pharmacology - Targets
2054
OpenTargets
ENSG00000106683
ZINC - FDA approved
LIMK1_HUMAN
ZINC - Substances
LIMK1_HUMAN
ZINC - Biogenic
LIMK1_HUMAN
ZINC target
P53667
PRO
P53667
PDB
5HVJ
,
5L6W
,
5NXC
,
8AAU
,
3S95
,
7ATU
,
7B8W
,
7ATS
,
5HVK
,
6WLY
ZINC - Investigational
LIMK1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000106683-LIMK1
GeneCards
P53667
Ensembl
ENST00000538333
,
ENSP00000444452
,
ENST00000336180
,
ENST00000435201
,
ENSP00000336740
,
ENSP00000414606
,
ENSG00000106683
Pharos - Targets
P53667
Orphanet
16358
ZINC - Predictions - Purchasable
LIMK1_HUMAN
HMDB Protein
HMDBP01538
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.722
3
UniProt:Q8WYL5 SSH1
0.676
6
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.619
5
UniProt:P57058 HUNK
0.573
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.558
2
IntAct:EBI-22432104 CCSB ORF ID
0.556
3
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.556
5
UniProt:Q8WYQ4-2 C22ORF15
0.556
3
UniProt:P46013 KI67
0.527
2
UniProt:P29066
6
ARRB1 [cytoplasmic vesicle membrane]
(R-RNO-351187)
ARRB1 [Golgi membrane]
(R-RNO-350831)
ARRB1 [lysosomal membrane]
(R-RNO-432701)
ARRB1 [endocytic vesicle membrane]
(R-RNO-9910882)
PolyUb-ARRB1 [cytosol]
(R-RNO-6783186)
ARRB1 [cytosol]
(R-RNO-264470)
0.524
2
UniProt:P29067
3
Arrb2 [endocytic vesicle membrane]
(R-RNO-9910881)
Arrb2 [cytosol]
(R-RNO-6783000)
Arrb2 [cytosol]
(R-RNO-416464)
0.524
2
UniProt:P63319
1
PRKCG [cytosol]
(R-RNO-58204)
0.524
3
UniProt:P50281 MMP14
4
MMP14 [Golgi membrane]
(R-HSA-9858808)
MMP14(21-582) [Golgi lumen]
(R-HSA-1604689)
MMP14 [Golgi lumen]
(R-HSA-1604724)
MMP14 [plasma membrane]
(R-HSA-1442472)
0.463
4
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