Reactome | p-T508-LIMK1 [cytosol]

p-T508-LIMK1 [cytosol]

Stable Identifier

R-HSA-399816

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Icon

Locations in the PathwayBrowser for interactor UniProt:P46013 KI67

Expand all

External Reference Information

External Reference

UniProt:P53667 LIMK1

Gene Names

LIMK1, LIMK

Chain

chain:1-647

Reference Genes

BioGPS Gene:3984 LIMK1

COSMIC (genes):LIMK1 LIMK1

CTD Gene:3984 LIMK1

dbSNP Gene:3984 LIMK1

ENSEMBL:ENSG00000106683 LIMK1

ENSEMBL_homo_sapiens_GENE:ENSG00000106683.15 LIMK1

HGNC:6613 LIMK1

KEGG Gene (Homo sapiens):3984 LIMK1

Monarch:3984 LIMK1

NCBI Gene:3984 LIMK1

OMIM:601329 LIMK1

UCSC:P53667 LIMK1

Reference Transcript

Other Identifiers

1015_s_at

11724614_at

11724615_at

11747621_a_at

17047045

204357_PM_s_at

204357_s_at

208372_s_at

3008109

3008110

3008111

3008113

3008116

3008117

3008118

3008119

3008122

3008123

3008125

3008126

3008127

3008128

3008129

3008130

3008131

3008134

3008135

3008138

3008140

3008141

3008142

3008143

3984

8133413

A_23_P215461

GE59301

GO:0000166

GO:0001673

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0006468

GO:0007010

GO:0007165

GO:0007266

GO:0007399

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0023052

GO:0030027

GO:0030036

GO:0030154

GO:0031072

GO:0032233

GO:0036211

GO:0038096

GO:0042995

GO:0043005

GO:0043149

GO:0043226

GO:0045773

GO:0046872

GO:0048675

GO:0048856

GO:0051444

GO:0051496

GO:0106310

GO:0140096

ILMN_1698649

ILMN_1797362

PH_hs_0002901

PH_hs_0035415

TC07000450.hg

U62293_rna1_s_at

g4587498_3p_a_at

g8051616_3p_a_at

Participates

as a member of

p-LIMK [cytosol] (Homo sapiens)

as an output of

as an input of

Dimerization of LIMK1 by Hsp90 (Homo sapiens)

as a component of

pLIMK dimer:HSP-90 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S,T508-LIMK1 [cytosol]

LIMK1 [cytosol]

Inferred To

phospho-p-T508-LIMK1 [cytosol] (Bos taurus)

phospho-p-T508-LIMK1 [cytosol] (Danio rerio)

phospho-p-T508-LIMK1 [cytosol] (Dictyostelium discoideum)

phospho-p-T508-LIMK1 [cytosol] (Drosophila melanogaster)

phospho-p-T508-LIMK1 [cytosol] (Gallus gallus)

phospho-p-T508-LIMK1 [cytosol] (Mus musculus)

phospho-p-T508-LIMK1 [cytosol] (Rattus norvegicus)

phospho-p-T508-LIMK1 [cytosol] (Sus scrofa)

phospho-p-T508-LIMK1 [cytosol] (Xenopus tropicalis)

phospho-LIMK1 [cytosol] (Canis familiaris)

Modified Residues

Name

O-phospho-L-threonine at 508

Coordinate

508

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001191355.1, NP_002305.1

ZINC - World Drugs

LIMK1_HUMAN

Guide to Pharmacology - Targets

2054

OpenTargets

ENSG00000106683

ZINC - FDA approved

LIMK1_HUMAN

ZINC - Substances

LIMK1_HUMAN

ZINC - Biogenic

LIMK1_HUMAN

ZINC target

P53667

PRO

P53667

PDB

5HVJ, 5L6W, 5NXC, 8AAU, 3S95, 7ATU, 7B8W, 7ATS, 5HVK, 6WLY

ZINC - Investigational

LIMK1_HUMAN

IntEnz

2.7.11.1

HPA

ENSG00000106683-LIMK1

GeneCards

P53667

Ensembl

ENST00000538333, ENSP00000444452, ENST00000336180, ENST00000435201, ENSP00000336740, ENSP00000414606, ENSG00000106683

Pharos - Targets

P53667

Orphanet

16358

ZINC - Predictions - Purchasable

LIMK1_HUMAN

HMDB Protein

HMDBP01538

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.722	3
UniProt:Q8WYL5 SSH1			0.676	6
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.619	5
UniProt:P57058 HUNK			0.573	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.558	2
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:O95835 LATS1	2	LATS1 [cytosol] (R-HSA-2028562) p-S909,T1079-LATS1 [cytosol] (R-HSA-2028551)	0.556	5
UniProt:Q8WYQ4-2 C22ORF15			0.556	3
UniProt:P46013 KI67			0.527	2
UniProt:P29066	6	ARRB1 [cytoplasmic vesicle membrane] (R-RNO-351187) ARRB1 [Golgi membrane] (R-RNO-350831) ARRB1 [lysosomal membrane] (R-RNO-432701) ARRB1 [endocytic vesicle membrane] (R-RNO-9910882) PolyUb-ARRB1 [cytosol] (R-RNO-6783186) ARRB1 [cytosol] (R-RNO-264470)	0.524	2
UniProt:P29067	3	Arrb2 [endocytic vesicle membrane] (R-RNO-9910881) Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.524	2
UniProt:P63319	1	PRKCG [cytosol] (R-RNO-58204)	0.524	3
UniProt:P50281 MMP14	4	MMP14 [Golgi membrane] (R-HSA-9858808) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472)	0.463	4

Cite Us!