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p-S144,T423-PAK1 [cytosol]
Stable Identifier
R-HSA-399819
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:Q96BD6 SPSB1
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Autophosphorylation of PAK1 (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
PAK1 phosphorylates LIMK1 (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
FLNA binds PAK1 (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
PAK1 phosphorylates FLNA (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
PAK1 phosphorylates LIMK1 (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
PAK1 phosphorylates myosin phosphatase (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13153 PAK1
Gene Names
PAK1
Chain
initiator methionine:, chain:2-545
Reference Genes
BioGPS Gene:5058 PAK1
COSMIC (genes):PAK1 PAK1
CTD Gene:5058 PAK1
dbSNP Gene:5058 PAK1
ENSEMBL:ENSG00000149269 PAK1
ENSEMBL_homo_sapiens_GENE:ENSG00000149269.10 PAK1
HGNC:8590 PAK1
KEGG Gene (Homo sapiens):5058 PAK1
Monarch:5058 PAK1
NCBI Gene:5058 PAK1
OMIM:602590 PAK1
UCSC:Q13153 PAK1
Reference Transcript
RefSeq:NM_002576.4 PAK1
RefSeq:XM_017017847.1 PAK1
RefSeq:XM_017017850.1 PAK1
RefSeq:XM_011545081.2 PAK1
RefSeq:XM_017017849.1 PAK1
RefSeq:NM_001128620.1 PAK1
RefSeq:XM_011545083.2 PAK1
RefSeq:XM_011545080.2 PAK1
RefSeq:XM_011545082.2 PAK1
RefSeq:XM_017017846.1 PAK1
RefSeq:XM_011545084.2 PAK1
RefSeq:XM_017017848.1 PAK1
Other Identifiers
11720103_a_at
11720104_a_at
1557_at
1558_g_at
1565772_PM_at
1565772_at
16742454
209615_PM_s_at
209615_s_at
226507_PM_at
226507_at
230100_PM_x_at
230100_x_at
3382862
3382863
3382864
3382865
3382866
3382867
3382869
3382871
3382873
3382874
3382876
3382878
3382879
3382881
3382884
3382886
3382891
3382893
3382895
3382896
3382900
3382909
43052_at
43053_g_at
47835_at
5058
60859_at
7950578
A_23_P75989
A_33_P3288609
A_33_P3784253
GE59021
GE86276
GO:0000166
GO:0001726
GO:0001934
GO:0002223
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005518
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005911
GO:0005925
GO:0006325
GO:0006338
GO:0006468
GO:0006887
GO:0006915
GO:0006974
GO:0007010
GO:0008092
GO:0008152
GO:0008284
GO:0012501
GO:0014704
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0023052
GO:0030018
GO:0030027
GO:0030036
GO:0030154
GO:0030335
GO:0030424
GO:0030425
GO:0031116
GO:0031267
GO:0031965
GO:0032587
GO:0032956
GO:0032991
GO:0033138
GO:0033148
GO:0035556
GO:0036211
GO:0038096
GO:0042060
GO:0042802
GO:0042995
GO:0043015
GO:0043226
GO:0043408
GO:0043507
GO:0046777
GO:0048012
GO:0048013
GO:0048754
GO:0048812
GO:0048856
GO:0048870
GO:0050770
GO:0051179
GO:0051496
GO:0060244
GO:0065003
GO:0070161
GO:0090063
GO:0098542
GO:0106310
GO:0140096
GO:1903608
HMNXSV003022832
HMNXSV003030470
Hs.23295.0.A1_3p_at
Hs.329996.0.A1_3p_s_at
ILMN_1767365
PH_hs_0003990
TC11002123.hg
TC11003261.hg
U24152_at
g1256421_3p_a_at
p18341
Participates
as a component of
pPAK1:Rac1-GTP [cytosol] (Homo sapiens)
p-S144,T423-PAK1:FLNA [cytosol] (Homo sapiens)
as an output of
PAK1 phosphorylates FLNA (Homo sapiens)
Autophosphorylation of PAK1 (Homo sapiens)
as an input of
FLNA binds PAK1 (Homo sapiens)
as a member of
p-S,T-PAK1,2,3 [cytosol] (Homo sapiens)
p-2Y-PAK [cytosol] (Homo sapiens)
as a candidate of
p-S,T-PAK1,2 [cytosol] (Homo sapiens)
This entity regulates
Negatively
Myosin phosphatase dephosphorylates myosin regulatory light chain
(Homo sapiens)
Other forms of this molecule
PAK1 [plasma membrane]
p-S144,T423-PAK1 [plasma membrane]
Active PAK1 [cytosol]
PAK1 [cytosol]
Inferred To
phospho-PAK1 [cytosol]
(Canis familiaris)
phospho-PAK1 [cytosol]
(Gallus gallus)
phospho-p-S144,T423-PAK1 [cytosol]
(Bos taurus)
phospho-p-S144,T423-PAK1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S144,T423-PAK1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S144,T423-PAK1 [cytosol]
(Drosophila melanogaster)
phospho-p-S144,T423-PAK1 [cytosol]
(Mus musculus)
phospho-p-S144,T423-PAK1 [cytosol]
(Rattus norvegicus)
phospho-p-S144,T423-PAK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S144,T423-PAK1 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S144,T423-PAK1 [cytosol]
(Sus scrofa)
phospho-p-S144,T423-PAK1 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 144
Coordinate
144
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 423
Coordinate
423
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_011543386.1
,
XP_016873335.1
,
XP_016873337.1
,
NP_001122092.1
,
XP_011543383.1
,
XP_016873339.1
,
XP_011543385.1
,
NP_002567.3
,
XP_016873336.1
,
XP_011543382.1
,
XP_016873338.1
,
XP_011543384.1
ZINC - World Drugs
PAK1_HUMAN
Guide to Pharmacology - Targets
2133
OpenTargets
ENSG00000149269
ZINC - FDA approved
PAK1_HUMAN
ZINC - Substances
PAK1_HUMAN
ZINC - Biogenic
PAK1_HUMAN
ZINC target
Q13153
PRO
Q13153
PDB
3DVP
,
2QME
,
4O0R
,
4ZJI
,
4P90
,
4ZJJ
,
1YHW
,
5IME
,
6B16
,
3FY0
,
5DEW
,
4EQC
,
5KBQ
,
8X5Z
,
1YHV
,
5DEY
,
7VTO
,
5KBR
,
4O0T
,
3FXZ
,
4ZLO
,
4DAW
,
2HY8
,
4ZY5
,
4ZY6
,
3Q52
,
3Q4Z
,
1ZSG
,
3Q53
,
5DFP
,
4ZY4
,
1F3M
ZINC - Investigational
PAK1_HUMAN
GeneCards
Q13153
HPA
ENSG00000149269-PAK1
Ensembl
ENSP00000348696
,
ENSG00000149269
,
ENST00000356341
,
ENSP00000278568
,
ENST00000278568
Pharos - Targets
Q13153
ZINC - Predictions - Purchasable
PAK1_HUMAN
HMDB Protein
HMDBP08499
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.977
28
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.953
16
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.944
15
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.939
13
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.798
7
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.778
4
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.744
5
UniProt:P21127 CDK11B
1
CDK11B [cytosol]
(R-HSA-380451)
0.69
4
UniProt:P63001 Rac1
7
RAC1 [ficolin-1-rich granule membrane]
(R-MMU-6804802)
RAC1 [secretory granule membrane]
(R-MMU-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-MMU-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-MMU-5672076)
Rac1 [plasma membrane]
(R-MMU-2316449)
RAC1 [cytosol]
(R-MMU-442615)
Rac1 [plasma membrane]
(R-MMU-421093)
0.688
3
UniProt:P60766 Cdc42
3
CDC42 [endoplasmic reticulum membrane]
(R-MMU-5672086)
CDC42 [cytosol]
(R-MMU-442630)
Cdc42 [plasma membrane]
(R-MMU-448841)
0.688
3
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.669
4
UniProt:Q9H4E5 RHOJ
1
RHOJ [plasma membrane]
(R-HSA-3006725)
0.666
4
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.666
4
UniProt:B3KX85 B3KX85
0.645
6
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.643
4
UniProt:P63000-1 RAC1
0.641
3
UniProt:Q92963 RIT1
1
RIT1 [plasma membrane]
(R-HSA-187703)
0.619
4
UniProt:P53667 LIMK1
3
p-S,T508-LIMK1 [cytosol]
(R-HSA-419610)
p-T508-LIMK1 [cytosol]
(R-HSA-399816)
LIMK1 [cytosol]
(R-HSA-397785)
0.619
5
UniProt:P62999
6
RAC1 [ficolin-1-rich granule membrane]
(R-CFA-6804802-2)
RAC1 [secretory granule membrane]
(R-CFA-6804770-2)
GGC-PalmC-RAC1 [plasma membrane]
(R-CFA-2316446-2)
RAC1 [endoplasmic reticulum membrane]
(R-CFA-5672076-2)
RAC1 [cytosol]
(R-CFA-442615-2)
RAC1 [plasma membrane]
(R-CFA-351141-2)
0.617
3
UniProt:Q7L0Q8 RHOU
4
p-Y254-RHOU [endosome membrane]
(R-HSA-9726860)
p-Y254-RHOU [plasma membrane]
(R-HSA-9726857)
RHOU [plasma membrane]
(R-HSA-194914)
RHOU [cytosol]
(R-HSA-194901)
0.589
3
UniProt:Q5PP90 Q5PP90
0.558
2
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:Q96BD6 SPSB1
1
SPSB1 [cytosol]
(R-HSA-976024)
0.556
3
UniProt:Q9H892-2 TTC12
0.556
3
IntAct:EBI-25839738 CCSB
0.556
3
UniProt:P11117 PPAL
0.556
3
UniProt:Q9BXU0 TEX12
1
TEX12 [nucleoplasm]
(R-HSA-912441)
0.556
3
UniProt:O15273 TCAP
1
TCAP [cytosol]
(R-HSA-390571)
0.556
3
UniProt:Q9Y2M5 KLHL20
1
KLHL20 [cytosol]
(R-HSA-976032)
0.556
3
UniProt:Q15759 MAPK11
4
p-T180,Y182-MAPK11 [nucleoplasm]
(R-HSA-198741)
MAPK11 [nucleoplasm]
(R-HSA-203790)
MAPK11 [cytosol]
(R-HSA-170989)
p-T180,Y182-MAPK11 [cytosol]
(R-HSA-171009)
0.556
3
UniProt:O60830 TIMM17B
2
TIMM17B [mitochondrial intermembrane space]
(R-HSA-1955371)
TIMM17B [mitochondrial inner membrane]
(R-HSA-1252138)
0.556
3
UniProt:P32243-2 OTX2
0.556
3
UniProt:Q8WZ73-3 Q8WZ733
0.556
3
UniProt:Q9NTN9-3 SEMA4G
0.556
3
IntAct:EBI-25839688 CCSB
0.556
3
UniProt:Q8N0Y2-2 ZNF444
0.556
3
UniProt:Q6NZ36-4 FAAP20
0.556
3
UniProt:Q9H0W9-3 C11ORF54
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q14847-2 LASP1
0.556
3
IntAct:EBI-25835277 CCSB
0.556
3
UniProt:Q8TDR4 TCP1L
0.556
3
UniProt:Q96A04 TSACC
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:Q8N490-3 PNKD
0.556
3
UniProt:P35611 ADD1
3
ADD1(634-737) [cytosol]
(R-HSA-202890)
ADD1(1-633) [cytosol]
(R-HSA-202891)
ADD1 [cytosol]
(R-HSA-201623)
0.556
3
UniProt:Q9Y239 NOD1
1
NOD1 [cytosol]
(R-HSA-168407)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P60953-2 CDC42
0.547
2
UniProt:Q9NVF7 FBX28
0.527
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.527
3
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.524
2
UniProt:Q05513-1 PRKCZ
0.499
5
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