Reactome | Inhibition of integrin activation by sequestering PIP5KIgamma

Inhibition of integrin activation by sequestering PIP5KIgamma

Stable Identifier

R-HSA-399936

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Inhibition of integrin activation by sequestering PIP5KIgamma

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Sema3A also mediates integrin inhibition by a mechanism involving PIPKI gamma 661, a phosphatidylinositol kinase that participates in integrin mediated focal adhesion assembly. The binding of talin to beta-integrin is required for integrin activation and is strengthened by PtdIns(4,5)P(2). PIPKI gamma 661, an enzyme that makes PtdIns(4,5)P(2), is targeted to focal adhesions by an association with talin. Sema3A induced dissociation of FARP2 from Plexin-A1 stimulates an interaction between FARP2 and PIPKI gamma 661. FARP2 inhibits PIPK gamma 661's kinase activity, and thus inhibits integrin mediated adhesion.

Literature References

PubMed ID	Title	Journal	Year
12422220	Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions Doughman, RL, Anderson, RA, Firestone, AJ, Bunce, MW, Ling, K	Nature	2002
10934324	Molecular basis of semaphorin-mediated axon guidance Nakamura, F, Strittmatter, SM, Kalb, RG	J Neurobiol	2000
16286926	FARP2 triggers signals for Sema3A-mediated axonal repulsion Zhang, H, Yoshida, J, Toyofuku, T, Kumanogoh, A, Sugimoto, T, Kikutani, H, Hori, M	Nat Neurosci	2005
16930978	Repulsion or adhesion: receptors make the call Halloran, MC, Wolman, MA	Curr Opin Cell Biol	2006