Autophosphorylation of PAK

Stable Identifier
R-HSA-399939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Autophosphorylation of PAK
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PAK is autophosphorylated at several sites but S-144 flanking the kinase inhibitor region and T-423 (S-141/T-402 in PAK-gamma) within the catalytic domain are the two conserved sites that regulate the catalytic activity.

Literature References
PubMed ID Title Journal Year
11278486 The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

Manser, E, Lim, L, Chong, C, Tan, L

J Biol Chem 2001
10075701 Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

Huang, Z, Traugh, JA, Tuazon, PT, Gatti, A

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane]

Physical Entity
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Autophosphorylation of PAK (Bos taurus)
Autophosphorylation of PAK (Caenorhabditis elegans)
Autophosphorylation of PAK (Canis familiaris)
Autophosphorylation of PAK (Danio rerio)
Autophosphorylation of PAK (Drosophila melanogaster)
Autophosphorylation of PAK (Gallus gallus)
Autophosphorylation of PAK (Mus musculus)
Autophosphorylation of PAK (Rattus norvegicus)
Autophosphorylation of PAK (Sus scrofa)
Autophosphorylation of PAK (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kikutani, H  (2009-09-02)
Kumanogoh, A  (2009-09-02)
Created
Garapati, P V  (2009-03-23)
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