Reactome | Phosphorylation of CRMPs by Cdk5

Phosphorylation of CRMPs by Cdk5

Stable Identifier

R-HSA-399944

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Cdk5:p35 complex is associated with Plexin-A through the actived form of Fyn. CRMPs are the downstream substrates for Cdk5. Cdk5 phosphorylates serine 522 of CRMPs. Phosphorylation of CRMPs mediates the Sema3A induced growth cone collapse.
Collapsin response mediator proteins (CRMPs) are five homologous cytosolic phosphoproteins (CRMP1–5) involved in neuronal differentiation and axonal guidance. These members oligomerize and exist as tetramers.

Literature References

PubMed ID	Title	Journal	Year
12372285	Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex Nakamura, F, Taniguchi, M, Ohno, S, Uchida, Y, Nakajima, O, Kudo, Y, Sasaki, Y, Kishida, R, Yagi, T, Nakayama, T, Goshima, Y, Ohshima, T, Cheng, C	Neuron	2002
17607942	The CRMP family of proteins and their role in Sema3A signaling Strittmatter, SM, Schmidt, EF	Adv Exp Med Biol	2007
14685275	Structural bases for CRMP function in plexin-dependent semaphorin3A signaling Strittmatter, SM, Elhabazi, A, Togashi, H, Schmidt, EF, Burley, SK, Deo, RC	EMBO J	2004