Reactome | Phosphorylation of LIMK-1 by PAK

Phosphorylation of LIMK-1 by PAK

Stable Identifier

R-HSA-399952

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. LIMK1 is one of the downstream targets of PAK1 and is activated through phosphorylation by PAK1 on T508 within its activation loop (Edwards et al. 1999, Aizawa et al. 2001). LIM-kinase is responsible for the tight regulation of the activity of cofilin (a protein that depolymerizes actin filaments) and thus maintains the balance between actin assembly and disassembly. Phosphorylated cofilin is inactive, resulting in stabilization of the actin cytoskeleton.

Literature References

PubMed ID	Title	Journal	Year
11276226	Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse Sekine-Aizawa, Y, Wakatsuki, S, Sehara-Fujisawa, A, Ohashi, K, Goshima, Y, Aizawa, H, Moriyama, K, Yahara, I, Ishii, A, Mizuno, K, Sasaki, Y	Nat Neurosci	2001
10559936	Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics Sanders, LC, Edwards, DC, Bokoch, GM, Gill, GN	Nat Cell Biol	1999