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ARHGEF25 [cytosol]
Stable Identifier
R-HSA-399959
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Guanine nucleotide exchange factor GEFT, p63RhoGEF, GEFT_HUMAN, Rac/Cdc42/Rho exchange factor GEFT
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
G alpha (q) binds to Trio family RhoGEFs (Homo sapiens)
G-protein alpha (q/11):Trio family RhoGEFs [plasma membrane] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
ARHGEF25 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86VW2 ARHGEF25
Gene Names
ARHGEF25, GEFT
Chain
chain:1-580
Reference Genes
BioGPS Gene:115557 ARHGEF25
COSMIC (genes):ARHGEF25 ARHGEF25
CTD Gene:115557 ARHGEF25
dbSNP Gene:115557 ARHGEF25
ENSEMBL:ENSG00000240771 ARHGEF25
ENSEMBL_homo_sapiens_GENE:ENSG00000240771.8 ARHGEF25
HGNC:30275 ARHGEF25
KEGG Gene (Homo sapiens):115557 ARHGEF25
Monarch:115557 ARHGEF25
NCBI Gene:115557 ARHGEF25
OMIM:610215 ARHGEF25
UCSC:Q86VW2 ARHGEF25
Reference Transcript
RefSeq:NM_182947.3 ARHGEF25
RefSeq:NM_001347933.1 ARHGEF25
RefSeq:NM_001111270.2 ARHGEF25
Other Identifiers
115557
11725006_a_at
16753064
227427_PM_at
227427_at
3418355
3418356
3418357
3418359
3418360
3418362
3418363
3418364
3418365
3418366
3418367
3418368
3418369
3418370
3418371
3418372
3418374
3418376
3418378
3418380
3418381
3418382
3418383
3418384
3418385
3418387
3418391
3418392
3418393
46184_at
7956551
A_14_P105969
A_23_P98844
A_24_P289299
GE574150
GO:0005085
GO:0005737
GO:0005829
GO:0005886
GO:0007411
GO:0016020
GO:0019898
GO:0023052
GO:0030016
GO:0030017
GO:0030154
GO:0043226
GO:0048856
GO:0051056
GO:0098772
HMNXSV003048554
Hs.61581.0.A1_3p_at
ILMN_1651536
ILMN_1741027
ILMN_2388965
PH_hs_0003913
TC12003247.hg
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
TRIO family RhoGEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
Inferred To
Dmel\CG15611 [cytosol]
(Drosophila melanogaster)
CG15612 [cytosol]
(Drosophila melanogaster)
trio [cytosol]
(Drosophila melanogaster)
Arhgef25 [cytosol]
(Mus musculus)
Arhgef25 [cytosol]
(Rattus norvegicus)
ARHGEF25 [cytosol]
(Bos taurus)
ARHGEF25 [cytosol]
(Canis familiaris)
ARHGEF25 [cytosol]
(Sus scrofa)
unc-73 [cytosol]
(Caenorhabditis elegans)
Homologues of ARHGEF25 [cytosol]
(Drosophila melanogaster)
arhgef25 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001334862.1
,
NP_891992.2
,
NP_001104740.1
OpenTargets
ENSG00000240771
HPA
ENSG00000240771-ARHGEF25
GeneCards
Q86VW2
Ensembl
ENSP00000335560
,
ENSG00000240771
,
ENST00000333972
,
ENSP00000484303
,
ENSP00000286494
,
ENST00000286494
,
ENST00000616622
PRO
Q86VW2
Pharos - Targets
Q86VW2
PDB
2RGN
HMDB Protein
HMDBP11499
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