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CHRM3 [plasma membrane]
Stable Identifier
R-HSA-399994
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Muscarinic Acetylcholine Receptor M3, M3
Locations in the PathwayBrowser for interactor UniProt:Q9Y6M7 SLC4A7
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)
CHRM3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20309 CHRM3
Gene Names
CHRM3
Chain
chain:1-590
Reference Genes
BioGPS Gene:1131 CHRM3
COSMIC (genes):CHRM3 CHRM3
CTD Gene:1131 CHRM3
dbSNP Gene:1131 CHRM3
ENSEMBL:ENSG00000133019 CHRM3
HGNC:1952 CHRM3
KEGG:hsa:1131 CHRM3
Monarch:1131 CHRM3
NCBI Gene:1131 CHRM3
OMIM:118494 CHRM3
UCSC:P20309 CHRM3
Reference Transcript
RefSeq:XM_017000156.1 CHRM3
RefSeq:NM_001347716.1 CHRM3
RefSeq:XM_011544044.2 CHRM3
RefSeq:XM_011544041.2 CHRM3
RefSeq:XM_017000157.1 CHRM3
RefSeq:XM_011544043.2 CHRM3
RefSeq:XM_011544046.2 CHRM3
RefSeq:XM_017000161.1 CHRM3
RefSeq:XM_017000159.1 CHRM3
RefSeq:XM_017000163.1 CHRM3
RefSeq:XM_017000155.1 CHRM3
RefSeq:NM_000740.3 CHRM3
RefSeq:XM_017000152.1 CHRM3
RefSeq:XM_005273032.3 CHRM3
RefSeq:XM_017000158.1 CHRM3
RefSeq:XM_017000160.1 CHRM3
RefSeq:XM_017000154.1 CHRM3
RefSeq:XM_017000162.1 CHRM3
RefSeq:XM_017000153.1 CHRM3
RefSeq:XM_011544047.2 CHRM3
Other Identifiers
1131
11731806_a_at
1553705_PM_a_at
1553705_a_at
1559633_PM_a_at
1559633_a_at
1559634_PM_at
1559634_at
1564339_PM_a_at
1564339_a_at
16679281
214596_PM_at
214596_at
2387607
2387619
2387626
2387627
2387628
2387629
2387630
2387631
2387635
2387637
2387638
2387646
2387647
2387663
2387666
2387667
2387668
2387669
2387670
2387671
2387695
2387704
2387705
2387706
2387708
242488_PM_at
242488_at
2488205
36759_at
42587_at
7910915
A_14_P121189
A_14_P125847
A_14_P135163
A_14_P201069
A_21_P0013981
A_23_P200843
A_23_P401472
A_24_P25137
A_24_P817236
GE59062
GE736956
GE869207
GO:0003012
GO:0003824
GO:0004435
GO:0004930
GO:0004993
GO:0005515
GO:0005783
GO:0005789
GO:0005886
GO:0006939
GO:0006940
GO:0007165
GO:0007186
GO:0007187
GO:0007197
GO:0007207
GO:0007213
GO:0007268
GO:0007271
GO:0007399
GO:0009925
GO:0016020
GO:0016323
GO:0016787
GO:0016907
GO:0019722
GO:0022600
GO:0023052
GO:0030425
GO:0032024
GO:0032412
GO:0036211
GO:0038023
GO:0042166
GO:0043226
GO:0045202
GO:0045211
GO:0045987
GO:0046541
GO:0048856
GO:0060089
GO:0095500
GO:0098664
GO:0099105
GO:1990806
HMNXSV003003293
HMNXSV003016403
Hs.140942.0.A1_3p_at
Hs.7138.0.S2_3p_at
Hs2.7138.1.S1_3p_s_at
Hs2.7138.2.S1_3p_at
Hs2.7138.3.S1_3p_s_at
ILMN_1710410
ILMN_1720364
ILMN_1887357
PH_hs_0030943
PH_hs_0034131
TC01005139.hg
TC01005141.hg
U29589_at
Participates
as an input of
Acetylcholine binds Muscarinic Acetylcholine Receptor M3 (Homo sapiens)
as a component of
Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane] (Homo sapiens)
as a member of
CHRM1,3,5 [plasma membrane] (Homo sapiens)
Inferred To
chrm3 [plasma membrane]
(Xenopus tropicalis)
gar-3 [plasma membrane]
(Caenorhabditis elegans)
mAChR-A [plasma membrane]
(Drosophila melanogaster)
CHRM3 [plasma membrane]
(Bos taurus)
CHRM3 [plasma membrane]
(Canis familiaris)
CHRM3 [plasma membrane]
(Sus scrofa)
Chrm3 [plasma membrane]
(Mus musculus)
Chrm3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011542346.1
,
XP_016855646.1
,
XP_016855645.1
,
XP_005273089.1
,
NP_000731.1
,
XP_011542345.1
,
XP_016855651.1
,
XP_011542343.1
,
NP_001334645.1
,
XP_016855648.1
,
XP_016855647.1
,
XP_016855649.1
,
XP_016855641.1
,
XP_016855642.1
,
XP_016855652.1
,
XP_016855650.1
,
XP_016855644.1
,
XP_011542348.1
,
XP_016855643.1
,
XP_011542349.1
ZINC - World Drugs
ACM3_HUMAN
Guide to Pharmacology - Targets
15
ENSEMBL
ENSP00000482377
,
ENST00000676153
,
ENSP00000502013
,
ENST00000675184
,
ENST00000255380
,
ENST00000676433
,
ENSP00000502349
,
ENSP00000502667
,
ENSP00000255380
,
ENST00000615928
OpenTargets
ENSG00000133019
ZINC - FDA approved
ACM3_HUMAN
ZINC - Substances
ACM3_HUMAN
ZINC - Biogenic
ACM3_HUMAN
ZINC target
P20309
PRO
P20309
GlyGen
P20309
PDB
2CSA
,
8E9W
,
8EA0
,
8E9Z
,
8E9Y
ZINC - Investigational
ACM3_HUMAN
ZINC - Metabolites
ACM3_HUMAN
HPA
ENSG00000133019-CHRM3
Pharos - Targets
P20309
Orphanet
CHRM3
ZINC - Predictions - Purchasable
ACM3_HUMAN
HMDB Protein
HMDBP10807
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08912 CHRM5
1
CHRM5 [plasma membrane]
(R-HSA-390678)
0.589
7
UniProt:Q92538 GBF1
2
GBF1 [cytosol]
(R-HSA-6807751)
GBF1 [Golgi membrane]
(R-HSA-199994)
0.527
2
UniProt:Q9UK39 NOCT
1
CCRN4L [nucleoplasm]
(R-HSA-508391)
0.527
2
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [early endosome membrane]
(R-HSA-5368451)
0.527
2
UniProt:Q13733 ATP1A4
1
ATP1A4 [plasma membrane]
(R-HSA-936914)
0.527
2
UniProt:O43156 TTI1
0.527
2
UniProt:O94829 IPO13
0.527
2
UniProt:Q9P2W9 STX18
1
STX18 [endoplasmic reticulum membrane]
(R-HSA-2029079)
0.527
2
UniProt:Q14849 STARD3
1
STARD3 [cytosol]
(R-HSA-5216089)
0.527
2
UniProt:Q96P70 IPO9
0.527
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.527
2
UniProt:Q9BX10 GTPBP2
2
GTPBP2 [extracellular region]
(R-HSA-8863001)
GTPBP2 [platelet alpha granule lumen]
(R-HSA-8862960)
0.527
2
UniProt:Q3ZCM7 TUBB8
3
Polyglycyl-TUBB8 [cytosol]
(R-HSA-8867423)
Polyglutamyl-TUBB8 [cytosol]
(R-HSA-8867387)
TUBB8 [cytosol]
(R-HSA-6805243)
0.527
2
UniProt:Q7Z4F1 LRP10
1
LRP10 [plasma membrane]
(R-HSA-2424275)
0.527
2
UniProt:Q9Y6M7 SLC4A7
1
SLC4A7 [plasma membrane]
(R-HSA-425552)
0.527
2
UniProt:Q96KP1 EXOC2
2
EXOC2 [cytosol]
(R-HSA-5623376)
EXOC2 [plasma membrane]
(R-HSA-264887)
0.527
2
UniProt:P68366 TUBA4A
9
TUBA4A [cytosol]
(R-HSA-191694)
TUBA4A [axonemal microtubule]
(R-HSA-5610443)
TUBA4A [extracellular region]
(R-HSA-350734)
Polyglutamyl-TUBA4A [cytosol]
(R-HSA-8867386)
L-isoglutamyl polyglycyl-TUBA4A [cytosol]
(R-HSA-8867378)
TUBA4A unfolded [cytosol]
(R-HSA-392771)
TUBA4A folding intermediate [cytosol]
(R-HSA-392800)
Ac K40 TUBA4A [axonemal microtubule]
(R-HSA-5624859)
AcK-TUBA4A [cytosol]
(R-HSA-5618318)
0.527
2
UniProt:Q9Y3E5 PTRH2
2
PTRH2 [mitochondrial outer membrane]
(R-HSA-5696909)
PolyUb-PTRH2 [mitochondrial outer membrane]
(R-HSA-6783190)
0.527
2
UniProt:P42356 PI4KA
1
PI4KA [cytosol]
(R-HSA-1604653)
0.527
2
UniProt:Q7Z4Q2 HEAT3
0.527
2
UniProt:P42338 PIK3CB
1
PIK3CB [cytosol]
(R-HSA-74788)
0.527
2
UniProt:O14939 PLD2
2
PLD2 [plasma membrane]
(R-HSA-2029075)
PLD2 [endoplasmic reticulum membrane]
(R-HSA-1498791)
0.527
2
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