Reactome | CARM1 [nucleoplasm]

CARM1 [nucleoplasm]

Stable Identifier

R-HSA-400139

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-arginine methyltransferase CARM1, CARM1_HUMAN, PRMT4

Locations in the PathwayBrowser for interactor UniProt:Q96PU8 QKI

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External Reference Information

External Reference

UniProt:Q86X55 CARM1

Gene Names

CARM1, PRMT4

Chain

initiator methionine:, chain:2-608

Reference Genes

BioGPS Gene:10498 CARM1

COSMIC (genes):CARM1 CARM1

CTD Gene:10498 CARM1

dbSNP Gene:10498 CARM1

ENSEMBL:ENSG00000142453 CARM1

ENSEMBL_homo_sapiens_GENE:ENSG00000142453.13 CARM1

HGNC:23393 CARM1

KEGG Gene (Homo sapiens):10498 CARM1

Monarch:10498 CARM1

NCBI Gene:10498 CARM1

OMIM:603934 CARM1

UCSC:Q86X55 CARM1

Reference Transcript

Other Identifiers

10498

11754363_s_at

16858321

212512_PM_s_at

212512_s_at

3820866

3820867

3820868

3820877

3820878

3820881

3820882

3820883

3820884

3820885

3820886

3820890

3820891

3820893

3820894

3820895

3820896

3820898

3820899

3820901

3820902

3820903

3820904

3820905

40182_s_at

8025766

A_14_P118491

A_33_P3256785

GE54518

GO:0000228

GO:0000976

GO:0003677

GO:0003713

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006260

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0008013

GO:0008168

GO:0008276

GO:0008284

GO:0008469

GO:0012501

GO:0016274

GO:0016571

GO:0016740

GO:0018216

GO:0023052

GO:0030154

GO:0030374

GO:0032259

GO:0033146

GO:0035242

GO:0035642

GO:0036211

GO:0042054

GO:0042393

GO:0043226

GO:0043596

GO:0045600

GO:0045943

GO:0048856

GO:0051591

GO:0070577

GO:0070611

GO:0071932

GO:0140096

GO:0140110

GO:0140297

GO:1904037

GO:2000171

HMNXSV003018692

Hs.143696.1.S1_3p_at

ILMN_1680134

PH_hs_0024183

TC19000188.hg

Participates

as an input of

as a component of

as a member of

Inferred To

CARM1 [nucleoplasm] (Bos taurus)

CARM1 [nucleoplasm] (Canis familiaris)

CARM1 [nucleoplasm] (Danio rerio)

CARM1 [nucleoplasm] (Drosophila melanogaster)

CARM1 [nucleoplasm] (Mus musculus)

CARM1 [nucleoplasm] (Rattus norvegicus)

CARM1 [nucleoplasm] (Sus scrofa)

carm1 [nucleoplasm] (Xenopus tropicalis)

Ghost homologue of CARM1 [nucleoplasm] (Gallus gallus)

Ghost homologue of CARM1 [nucleoplasm] (Saccharomyces cerevisiae)

Ghost homologue of CARM1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_005259765.1, NP_954592.1

ZINC - World Drugs

CARM1_HUMAN

Guide to Pharmacology - Targets

1255

OpenTargets

ENSG00000142453

ZINC - Substances

CARM1_HUMAN

ZINC target

Q86X55

ZINC - Biogenic

CARM1_HUMAN

PRO

Q86X55

PDB

6S70, 8G2H, 6ARJ, 6S71, 5DX0, 5DX1, 7FAJ, 5DWQ, 7FAI, 6D2L, 4IKP, 6S7C, 6S7B, 5U4X, 8SIH, 8SIG, 5DXJ, 6S7A, 6S79, 6ARV, 6DVR, 2Y1X, 5DXA, 6IZQ, 6S74, 7U9I, 5DX8, 2Y1W, 6S77, 8G2I

ZINC - Metabolites

CARM1_HUMAN

IntEnz

2.1.1.319

HPA

ENSG00000142453-CARM1

GeneCards

Q86X55

Ensembl

ENST00000344150, ENSP00000340934, ENST00000327064, ENSG00000142453, ENSP00000325690

Pharos - Targets

Q86X55

ZINC - Predictions - Purchasable

CARM1_HUMAN

HMDB Protein

HMDBP09009

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.623	13
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.611	4
UniProt:Q05826	3	CEBPB [nucleoplasm] (R-GGA-381378) phospho-CEBPB [nucleoplasm] (R-GGA-3857343) phospho-CEBPB [nucleoplasm] (R-GGA-3857339)	0.602	3
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.527	2
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.527	2
UniProt:P17676 CEBPB	3	p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) p-T235-CEBPB [nucleoplasm] (R-HSA-3857343) CEBPB [nucleoplasm] (R-HSA-381378)	0.524	2
UniProt:Q96PU8 QKI	2	QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466) QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546)	0.508	2
UniProt:A0A1U8QN96 A0A1U8QN96			0.508	2
UniProt:O43809 NUDT21	1	NUDT21 [nucleoplasm] (R-HSA-72010)	0.508	2
UniProt:Q96EY1 DNJA3			0.508	2
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [extracellular region] (R-HSA-349735) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [cytosol] (R-HSA-71492)	0.499	2
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.499	2
UniProt:Q8IUC6 TICAM1	4	TICAM1 S186L [cytosol] (R-HSA-5607964) TICAM1 R141* [cytosol] (R-HSA-5602690) TICAM1 [cytosol] (R-HSA-166170) TICAM1 [endosome membrane] (R-HSA-450316)	0.499	2
UniProt:P55854 SUMO3	5	SUMO3(1-103) [nucleoplasm] (R-HSA-2990830) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627) lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm] (R-HSA-9761547) SUMO3 [nucleoplasm] (R-HSA-2984269) UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611)	0.499	2
UniProt:Q9Q2G4 Q9Q2G4			0.462	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.462	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.462	3

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