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EHHADH [peroxisomal matrix]
Stable Identifier
R-HSA-400155
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
Peroxisomal bifunctional enzyme
Locations in the PathwayBrowser for interactor UniProt:Q8ND90 PNMA1
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Peroxisomal lipid metabolism (Homo sapiens)
Beta-oxidation of very long chain fatty acids (Homo sapiens)
EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA (Homo sapiens)
EHHADH [peroxisomal matrix] (Homo sapiens)
EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA (Homo sapiens)
EHHADH [peroxisomal matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
1651711
Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro
Chen, GL
,
Hoefler, G
,
Balfe, A
,
Erwa, W
,
Chen, WW
,
Aikawa, J
,
Gaertner, J
Biochem. Biophys. Res. Commun.
1991
External Reference Information
External Reference
UniProt:Q08426 EHHADH
Gene Names
EHHADH, ECHD
Chain
chain:1-723
Reference Genes
BioGPS Gene:1962 EHHADH
COSMIC (genes):EHHADH EHHADH
CTD Gene:1962 EHHADH
dbSNP Gene:1962 EHHADH
ENSEMBL:ENSG00000113790 EHHADH
ENSEMBL_homo_sapiens_GENE:ENSG00000113790.11 EHHADH
HGNC:3247 EHHADH
KEGG Gene (Homo sapiens):1962 EHHADH
Monarch:1962 EHHADH
NCBI Gene:1962 EHHADH
OMIM:607037 EHHADH
UCSC:Q08426 EHHADH
Reference Transcript
RefSeq:NM_001966.3 EHHADH
RefSeq:NM_001166415.1 EHHADH
RefSeq:XM_011512517.1 EHHADH
Other Identifiers
11724039_at
11724040_at
11747115_a_at
16962277
1962
205222_PM_at
205222_at
2708721
2708722
2708723
2708724
2708725
2708726
2708727
2708731
2708732
2708733
2708736
2708745
2708748
2708749
2708758
2708760
31871_r_at
8092523
A_24_P123119
GE57572
GO:0003824
GO:0003857
GO:0004165
GO:0004300
GO:0005515
GO:0005777
GO:0005782
GO:0005829
GO:0006629
GO:0006631
GO:0006635
GO:0008152
GO:0016491
GO:0016509
GO:0016616
GO:0016829
GO:0016853
GO:0016863
GO:0018812
GO:0019899
GO:0033540
GO:0043226
GO:0070403
HMNXSV003047374
ILMN_1701507
L07077_at
PH_hs_0025237
TC03002076.hg
g4503496_3p_at
Participates
as a member of
Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)
Other forms of this molecule
EHHADH [cytosol]
Inferred To
EHHADH [peroxisomal matrix]
(Bos taurus)
EHHADH [peroxisomal matrix]
(Canis familiaris)
EHHADH [peroxisomal matrix]
(Danio rerio)
EHHADH [peroxisomal matrix]
(Gallus gallus)
EHHADH [peroxisomal matrix]
(Mus musculus)
EHHADH [peroxisomal matrix]
(Rattus norvegicus)
EHHADH [peroxisomal matrix]
(Sus scrofa)
ech-8 [peroxisomal matrix]
(Caenorhabditis elegans)
ehhadh [peroxisomal matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001957.2
,
XP_011510819.1
,
NP_001159887.1
OpenTargets
ENSG00000113790
IntEnz
1.1.1.35
GeneCards
Q08426
HPA
ENSG00000113790-EHHADH
Ensembl
ENST00000231887
,
ENSG00000113790
,
ENST00000456310
,
ENSP00000387746
,
ENSP00000231887
PRO
Q08426
Pharos - Targets
Q08426
Orphanet
17357
HMDB Protein
HMDBP00380
Interactors (115)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WV44 TRIM41
1
TRIM41 [cytosol]
(R-HSA-5688975)
0.831
8
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.781
8
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.743
6
UniProt:Q96C00 ZBTB9
0.718
6
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.718
6
UniProt:P17661 DES
1
DES [cytosol]
(R-HSA-390570)
0.718
6
UniProt:Q68D86 C102B
0.666
4
UniProt:O43805 SSNA1
1
SSNA1 [cytosol]
(R-HSA-380255)
0.666
4
UniProt:Q7L273 KCTD9
0.666
4
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.666
4
UniProt:P35520 CBS
1
PXLP-K119-CBS [cytosol]
(R-HSA-1614563)
0.666
4
UniProt:P63261 ACTG1
3
ACTG1 [cytosol]
(R-HSA-201858)
ACTG1 [lysosomal membrane]
(R-HSA-196169)
ACTG1 [plasma membrane]
(R-HSA-196044)
0.666
4
UniProt:P29144 TPP2
1
TPP2 [cytosol]
(R-HSA-983068)
0.666
5
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.666
4
UniProt:Q8IVP5 FUNDC1
4
p-S17-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8948140)
p-S13,Y18-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934915)
FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934922)
p-S13-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934910)
0.666
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.601
4
UniProt:P20807-4 CAPN3
0.556
3
UniProt:Q53FP2 NACHO
0.556
3
UniProt:Q8TEZ7 PAQR8
0.556
3
UniProt:P49447 CY561
0.556
3
UniProt:Q9BZL4 PP12C
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:Q8IV36 HID1
0.556
3
UniProt:P78563-4 ADARB1
0.556
3
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q8WV19 SFT2A
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:Q8N3Y7 SDR16C5
1
RDHE2 [endoplasmic reticulum membrane]
(R-HSA-5621649)
0.556
3
UniProt:P36941 LTBR
1
LTBR [plasma membrane]
(R-HSA-5668750)
0.556
3
UniProt:Q969X5 ERGI1
0.556
3
IntAct:EBI-23324079 CCSB ORF ID
0.556
3
UniProt:O95214 LERL1
0.556
5
UniProt:Q15849 SLC14A2
1
SLC14A2 [plasma membrane]
(R-HSA-444115)
0.556
3
UniProt:O14684 PTGES
1
PTGES [endoplasmic reticulum membrane]
(R-HSA-2142717)
0.556
3
UniProt:Q96BR9 ZBT8A
0.556
3
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.556
3
UniProt:P19474 TRIM21
1
TRIM21 [cytosol]
(R-HSA-976051)
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:O00291 HIP1
7
HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol]
(R-HSA-9711952)
HIP1(1-1019)-ALK(1058-1620) [cytosol]
(R-HSA-9711970)
HIP1(1-963)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711972)
HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9711965)
HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol]
(R-HSA-9711956)
HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711975)
HIP1 [cytosol]
(R-HSA-8868153)
0.556
3
UniProt:Q9UH62 ARMCX3
1
ARMCX3 [mitochondrial outer membrane]
(R-HSA-9714514)
0.556
3
UniProt:Q9NQ48 LZTFL1
1
LZTFL1 [cytosol]
(R-HSA-5617789)
0.556
3
UniProt:Q86X02 CDR2L
0.556
3
UniProt:Q9Y592-2 CEP83
0.556
3
UniProt:Q9BV19 CA050
0.556
3
UniProt:P60508 SYCY2
0.556
3
UniProt:Q8N8X9 MB213
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q9HCK0 ZBT26
0.556
5
UniProt:Q1KLZ0 Q1KLZ0
0.556
3
UniProt:O43759-2 SYNGR1
0.556
3
UniProt:Q9Y281 COF2
0.556
3
UniProt:Q9C035-3 TRIM5
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:O75569 PRKRA
2
p-S246,S287-PRKRA [cytosol]
(R-HSA-9834791)
PRKRA [cytosol]
(R-HSA-2399897)
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q96GQ5 RUSF1
0.556
3
UniProt:Q5JTZ9 AARS2
1
AARS2 [mitochondrial matrix]
(R-HSA-379653)
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:O75208 COQ9
1
COQ9 [mitochondrial inner membrane]
(R-HSA-8932994)
0.556
3
UniProt:Q16637 SMN1
2
SMN1 [nucleoplasm]
(R-HSA-191892)
SMN1 [cytosol]
(R-HSA-191839)
0.556
3
UniProt:O43761 SNG3
0.556
3
UniProt:Q8N5K1 CISD2
0.556
3
UniProt:Q8IYE1 CCD13
0.556
3
UniProt:Q8N2N9-4 ANKRD36B
0.556
3
UniProt:Q8NBI2 CYAC3
0.556
3
UniProt:P56856 CLDN18
2
CLDN18 [plasma membrane]
(R-HSA-432972)
CLDN18 [cell junction]
(R-HSA-434607)
0.556
3
UniProt:Q9NS64 RPRM
0.556
3
UniProt:Q08AM6 VAC14
3
VAC14 [Golgi membrane]
(R-HSA-1806235)
VAC14 [early endosome membrane]
(R-HSA-1806207)
VAC14 [late endosome membrane]
(R-HSA-1806219)
0.556
3
UniProt:Q04323-2 UBXN1
0.556
3
UniProt:Q9BTD3 TM121
0.556
3
UniProt:Q16585 SGCB
0.556
3
UniProt:Q96IK5 GMCL1
0.556
3
UniProt:P80188 LCN2
2
LCN2 [specific granule lumen]
(R-HSA-6799614)
LCN2 [extracellular region]
(R-HSA-5215934)
0.556
3
UniProt:Q86X19 TMM17
0.556
3
UniProt:P54849 EMP1
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q9NP94 SLC39A2
1
SLC39A2 [plasma membrane]
(R-HSA-442395)
0.556
3
UniProt:Q96RE7 NACC1
0.556
3
UniProt:Q4V328 GRAP1
0.556
3
UniProt:Q9BUP3-3 HTATIP2
0.556
3
IntAct:EBI-22326698 CCSB ORF ID
0.556
3
UniProt:Q7Z6G3-2 NECAB2
0.556
3
UniProt:Q96PV4 PNMA5
0.556
3
UniProt:Q71RC9 SMIM5
0.556
3
UniProt:Q9NP64 ZCC17
0.556
3
UniProt:Q96Q80 DERL3
1
DERL3 [endoplasmic reticulum membrane]
(R-HSA-8866516)
0.556
3
UniProt:Q9NP66 HM20A
0.556
3
UniProt:Q96DT7-3 ZBTB10
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:P35372-10 OPRM1
0.556
3
UniProt:Q96HR9-2 REEP6
0.556
3
UniProt:Q6UWN5 LYPD5
2
cleaved GPI-LYPD5 [extracellular region]
(R-HSA-8941140)
GPI-LYPD5 [plasma membrane]
(R-HSA-8940779)
0.556
3
UniProt:Q9Y2D8 ADIP
0.556
3
UniProt:Q92915-2 FGF14
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:O00501 CLDN5
2
CLDN5 [cell junction]
(R-HSA-421264)
CLDN5 [plasma membrane]
(R-HSA-419991)
0.556
3
UniProt:Q9NX76 CMTM6
3
CMTM6 [specific granule membrane]
(R-HSA-6800916)
CMTM6 [plasma membrane]
(R-HSA-6806275)
CMTM6 [azurophil granule membrane]
(R-HSA-6799141)
0.556
3
UniProt:Q5T9G4-2 ARMC12
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:P49760 CLK2
0.556
3
UniProt:Q9P0S3 ORMDL1
1
ORMDL1 [endoplasmic reticulum membrane]
(R-HSA-8865584)
0.556
3
UniProt:Q8N9W6-4 BOLL
0.556
3
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
3
UniProt:Q6ZMJ2-2 SCARA5
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q969Q1 TRIM63
1
TRIM63 [cytosol]
(R-HSA-976020)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:Q8NBQ5 HSD17B11
1
HSD17B11 [cytosol]
(R-HSA-5693370)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
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