Reactome | EHHADH [peroxisomal matrix]

EHHADH [peroxisomal matrix]

Stable Identifier

R-HSA-400155

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

Peroxisomal bifunctional enzyme

Locations in the PathwayBrowser for interactor UniProt:Q9Y2D8 ADIP

Expand all

Literature References

PubMed ID	Title	Journal	Year
1651711	Import of human bifunctional enzyme into peroxisomes of human hepatoma cells in vitro Chen, GL, Hoefler, G, Balfe, A, Erwa, W, Chen, WW, Aikawa, J, Gaertner, J	Biochem. Biophys. Res. Commun.	1991

External Reference Information

External Reference

UniProt:Q08426 EHHADH

Gene Names

EHHADH, ECHD

Chain

chain:1-723

Reference Genes

BioGPS Gene:1962 EHHADH

COSMIC (genes):EHHADH EHHADH

CTD Gene:1962 EHHADH

dbSNP Gene:1962 EHHADH

ENSEMBL:ENSG00000113790 EHHADH

ENSEMBL_homo_sapiens_GENE:ENSG00000113790.11 EHHADH

HGNC:3247 EHHADH

KEGG Gene (Homo sapiens):1962 EHHADH

Monarch:1962 EHHADH

NCBI Gene:1962 EHHADH

OMIM:607037 EHHADH

UCSC:Q08426 EHHADH

Reference Transcript

Other Identifiers

11724039_at

11724040_at

11747115_a_at

16962277

1962

205222_PM_at

205222_at

2708721

2708722

2708723

2708724

2708725

2708726

2708727

2708731

2708732

2708733

2708736

2708745

2708748

2708749

2708758

2708760

31871_r_at

8092523

A_24_P123119

GE57572

GO:0003824

GO:0003857

GO:0004165

GO:0004300

GO:0005515

GO:0005777

GO:0005782

GO:0005829

GO:0006629

GO:0006631

GO:0006635

GO:0008152

GO:0016491

GO:0016509

GO:0016616

GO:0016829

GO:0016853

GO:0016863

GO:0018812

GO:0019899

GO:0033540

GO:0043226

GO:0070403

HMNXSV003047374

ILMN_1701507

L07077_at

PH_hs_0025237

TC03002076.hg

g4503496_3p_at

Participates

as a member of

Cargo proteins containing PTS1 [peroxisomal matrix] (Homo sapiens)

Other forms of this molecule

EHHADH [cytosol]

Inferred To

EHHADH [peroxisomal matrix] (Bos taurus)

EHHADH [peroxisomal matrix] (Canis familiaris)

EHHADH [peroxisomal matrix] (Danio rerio)

EHHADH [peroxisomal matrix] (Gallus gallus)

EHHADH [peroxisomal matrix] (Mus musculus)

EHHADH [peroxisomal matrix] (Rattus norvegicus)

EHHADH [peroxisomal matrix] (Sus scrofa)

ech-8 [peroxisomal matrix] (Caenorhabditis elegans)

ehhadh [peroxisomal matrix] (Xenopus tropicalis)

Cross References

RefSeq

NP_001957.2, XP_011510819.1, NP_001159887.1

OpenTargets

ENSG00000113790

IntEnz

1.1.1.35

GeneCards

Q08426

HPA

ENSG00000113790-EHHADH

Ensembl

ENST00000231887, ENSG00000113790, ENST00000456310, ENSP00000387746, ENSP00000231887

PRO

Q08426

Pharos - Targets

Q08426

Orphanet

17357

HMDB Protein

HMDBP00380

Interactors (115)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WV44 TRIM41	1	TRIM41 [cytosol] (R-HSA-5688975)	0.831	8
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.781	8
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.743	6
UniProt:Q96C00 ZBTB9			0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.718	6
UniProt:Q68D86 C102B			0.666	4
UniProt:O43805 SSNA1	1	SSNA1 [cytosol] (R-HSA-380255)	0.666	4
UniProt:Q7L273 KCTD9			0.666	4
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.666	4
UniProt:P35520 CBS	1	PXLP-K119-CBS [cytosol] (R-HSA-1614563)	0.666	4
UniProt:P63261 ACTG1	3	ACTG1 [cytosol] (R-HSA-201858) ACTG1 [lysosomal membrane] (R-HSA-196169) ACTG1 [plasma membrane] (R-HSA-196044)	0.666	4
UniProt:P29144 TPP2	1	TPP2 [cytosol] (R-HSA-983068)	0.666	5
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB [nucleoplasm] (R-HSA-3321990) ACTB [cytosol] (R-HSA-201861) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [plasma membrane] (R-HSA-196016)	0.666	4
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.666	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.601	4
UniProt:P20807-4 CAPN3			0.556	3
UniProt:Q53FP2 NACHO			0.556	3
UniProt:Q8TEZ7 PAQR8			0.556	3
UniProt:P49447 CY561			0.556	3
UniProt:Q9BZL4 PP12C			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q8IV36 HID1			0.556	3
UniProt:P78563-4 ADARB1			0.556	3
UniProt:Q8ND90 PNMA1			0.556	3
UniProt:Q8WV19 SFT2A			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q8N3Y7 SDR16C5	1	RDHE2 [endoplasmic reticulum membrane] (R-HSA-5621649)	0.556	3
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.556	3
UniProt:Q969X5 ERGI1			0.556	3
IntAct:EBI-23324079 CCSB ORF ID			0.556	3
UniProt:O95214 LERL1			0.556	5
UniProt:Q15849 SLC14A2	1	SLC14A2 [plasma membrane] (R-HSA-444115)	0.556	3
UniProt:O14684 PTGES	1	PTGES [endoplasmic reticulum membrane] (R-HSA-2142717)	0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:Q8N5M9 JAGN1			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:Q9UH62 ARMCX3	1	ARMCX3 [mitochondrial outer membrane] (R-HSA-9714514)	0.556	3
UniProt:Q9NQ48 LZTFL1	1	LZTFL1 [cytosol] (R-HSA-5617789)	0.556	3
UniProt:Q86X02 CDR2L			0.556	3
UniProt:Q9Y592-2 CEP83			0.556	3
UniProt:Q9BV19 CA050			0.556	3
UniProt:P60508 SYCY2			0.556	3
UniProt:Q8N8X9 MB213			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q9HCK0 ZBT26			0.556	5
UniProt:Q1KLZ0 Q1KLZ0			0.556	3
UniProt:O43759-2 SYNGR1			0.556	3
UniProt:Q9Y281 COF2			0.556	3
UniProt:Q9C035-3 TRIM5			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:Q5JTZ9 AARS2	1	AARS2 [mitochondrial matrix] (R-HSA-379653)	0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:O75208 COQ9	1	COQ9 [mitochondrial inner membrane] (R-HSA-8932994)	0.556	3
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q8N5K1 CISD2			0.556	3
UniProt:Q8IYE1 CCD13			0.556	3
UniProt:Q8N2N9-4 ANKRD36B			0.556	3
UniProt:Q8NBI2 CYAC3			0.556	3
UniProt:P56856 CLDN18	2	CLDN18 [plasma membrane] (R-HSA-432972) CLDN18 [cell junction] (R-HSA-434607)	0.556	3
UniProt:Q9NS64 RPRM			0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
UniProt:Q9BTD3 TM121			0.556	3
UniProt:Q16585 SGCB			0.556	3
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:P80188 LCN2	2	LCN2 [specific granule lumen] (R-HSA-6799614) LCN2 [extracellular region] (R-HSA-5215934)	0.556	3
UniProt:Q86X19 TMM17			0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:Q96RE7 NACC1			0.556	3
UniProt:Q4V328 GRAP1			0.556	3
UniProt:Q9BUP3-3 HTATIP2			0.556	3
IntAct:EBI-22326698 CCSB ORF ID			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q71RC9 SMIM5			0.556	3
UniProt:Q9NP64 ZCC17			0.556	3
UniProt:Q96Q80 DERL3	1	DERL3 [endoplasmic reticulum membrane] (R-HSA-8866516)	0.556	3
UniProt:Q9NP66 HM20A			0.556	3
UniProt:Q96DT7-3 ZBTB10			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:P35372-10 OPRM1			0.556	3
UniProt:Q96HR9-2 REEP6			0.556	3
UniProt:Q6UWN5 LYPD5	2	cleaved GPI-LYPD5 [extracellular region] (R-HSA-8941140) GPI-LYPD5 [plasma membrane] (R-HSA-8940779)	0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q92915-2 FGF14			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:Q9NX76 CMTM6	3	CMTM6 [specific granule membrane] (R-HSA-6800916) CMTM6 [plasma membrane] (R-HSA-6806275) CMTM6 [azurophil granule membrane] (R-HSA-6799141)	0.556	3
UniProt:Q5T9G4-2 ARMC12			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:P49760 CLK2			0.556	3
UniProt:Q9P0S3 ORMDL1	1	ORMDL1 [endoplasmic reticulum membrane] (R-HSA-8865584)	0.556	3
UniProt:Q8N9W6-4 BOLL			0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q6ZMJ2-2 SCARA5			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9NR28 DIABLO	2	DIABLO [mitochondrial intermembrane space] (R-HSA-64637) DIABLO [cytosol] (R-HSA-114298)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q969Q1 TRIM63	1	TRIM63 [cytosol] (R-HSA-976020)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3

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