Reactome | PPARA [nucleoplasm]

PPARA [nucleoplasm]

Stable Identifier

R-HSA-400186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Peroxisome proliferator-activated receptor alpha, PPAR-alpha

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Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Cytoprotection by HMOX1 (Homo sapiens)
      - Fatty acid ligands activate PPARA (Homo sapiens)
        
        PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARA:fatty acid (Activated PPARA) [nucleoplasm] (Homo sapiens)
        
        PPARA [nucleoplasm] (Homo sapiens)
        
        PPARA:RXRA:Corepressors [nucleoplasm] (Homo sapiens)
        
        PPARA:RXRA heterodimer [nucleoplasm] (Homo sapiens)
        
        PPARA [nucleoplasm] (Homo sapiens)
  - Heme signaling (Homo sapiens)
    - Expression of NPAS2 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARA:fatty acid (Activated PPARA) [nucleoplasm] (Homo sapiens)
        
        PPARA [nucleoplasm] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
    - Expression of ALAS1 (Homo sapiens)
      - PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
        
        Activated PPARA:RXRA [nucleoplasm] (Homo sapiens)
        
        PPARA:fatty acid (Activated PPARA) [nucleoplasm] (Homo sapiens)
        
        PPARA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q07869 PPARA

Gene Names

PPARA, NR1C1, PPAR

Chain

chain:1-468

Reference Genes

BioGPS Gene:5465 PPARA

COSMIC (genes):PPARA PPARA

CTD Gene:5465 PPARA

dbSNP Gene:5465 PPARA

ENSEMBL:ENSG00000186951 PPARA

HGNC:9232 PPARA

KEGG:hsa:5465 PPARA

Monarch:5465 PPARA

NCBI Gene:5465 PPARA

OMIM:170998 PPARA

UCSC:Q07869 PPARA

Reference Transcript

Other Identifiers

11724411_a_at

11724412_a_at

11724413_s_at

11758903_at

11763524_a_at

11763680_a_at

11763681_x_at

11764026_at

1556064_PM_at

1556064_at

1558631_PM_at

1558631_at

16931339

16931358

206870_PM_at

206870_at

210771_PM_at

210771_at

223437_PM_at

223437_at

223438_PM_s_at

223438_s_at

226978_PM_at

226978_at

237142_PM_at

237142_at

244689_PM_at

244689_at

3948959

3948960

3948962

3948963

3948964

3948965

3948966

3948967

3948968

3948971

3948973

3948974

3948979

3948980

3948981

3948983

3948986

3948987

3948988

3948989

3948992

3948994

3948995

3948996

3948997

3948998

3948999

3949000

3949001

3949002

3949003

3949010

47512_at

5465

59974_r_at

8073826

83401_at

86444_at

90256_at

929_at

A_14_P133767

A_23_P211643

A_24_P417036

A_24_P570049

A_32_P198371

GE62555

GE83467

GE87082

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001216

GO:0001223

GO:0001227

GO:0001228

GO:0001666

GO:0003677

GO:0003700

GO:0003707

GO:0004879

GO:0005515

GO:0005634

GO:0005654

GO:0005975

GO:0006094

GO:0006355

GO:0006357

GO:0006629

GO:0006631

GO:0007507

GO:0007584

GO:0008270

GO:0008289

GO:0008544

GO:0009267

GO:0009755

GO:0010468

GO:0010565

GO:0010745

GO:0010883

GO:0010887

GO:0010891

GO:0014070

GO:0019217

GO:0019902

GO:0019904

GO:0030154

GO:0030512

GO:0030522

GO:0031435

GO:0031624

GO:0032000

GO:0032099

GO:0032868

GO:0032922

GO:0035095

GO:0038023

GO:0042060

GO:0042157

GO:0042752

GO:0043226

GO:0043401

GO:0043565

GO:0044877

GO:0045471

GO:0045722

GO:0045776

GO:0045820

GO:0045893

GO:0045923

GO:0045944

GO:0046209

GO:0046321

GO:0046872

GO:0046889

GO:0048511

GO:0048856

GO:0050728

GO:0051525

GO:0051898

GO:0060089

GO:0061052

GO:0061629

GO:0070166

GO:0071332

GO:0097371

GO:0140110

GO:0140297

GO:1900016

GO:1902894

GO:1903038

GO:1903427

GO:1903944

GO:1904189

GO:2000191

GO:2000272

GO:2001171

HMNXSV003000005

HMNXSV003014939

Hs.153393.0.A1_3p_at

Hs.272006.0.A1_3p_at

Hs.272006.0.A1_3p_x_at

Hs.275711.0.S2_3p_at

Hs.286014.0.S1_3p_at

Hs2.199700.1.A1_3p_at

Hs2.391179.1.A1_3p_at

ILMN_1659346

ILMN_1700488

ILMN_2362847

L02932_at

PH_hs_0023352

PH_hs_0026238

PH_hs_0034827

PH_hs_0035085

TC22000391.hg

TC22000392.hg

TC22001152.hg

TC22001154.hg

TC22001155.hg

TC22001156.hg

g12652612_3p_at

g12652612_3p_x_at

g13278779_3p_a_at

g7549810_3p_at

p28699

p33879

Participates

as an input of

as an output of

as a member of

NR [nucleoplasm] (Homo sapiens)

as a component of

Other forms of this molecule

monoSUMO1-K185-PPARA [nucleoplasm]

Inferred To

nhr-2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of PPARA [nucleoplasm] (Caenorhabditis elegans)

Eip75B [nucleoplasm] (Drosophila melanogaster)

PPARA [nucleoplasm] (Bos taurus)

PPARA [nucleoplasm] (Canis familiaris)

PPARA [nucleoplasm] (Gallus gallus)

PPARA [nucleoplasm] (Sus scrofa)

pparab [nucleoplasm] (Danio rerio)

nhr-7 [nucleoplasm] (Caenorhabditis elegans)

nhr-85 [nucleoplasm] (Caenorhabditis elegans)

ppara [nucleoplasm] (Xenopus tropicalis)

sex-1 [nucleoplasm] (Caenorhabditis elegans)

Ppara [nucleoplasm] (Mus musculus)

Ppara [nucleoplasm] (Rattus norvegicus)

unc-55 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011528544.1, XP_011528545.1, XP_006724332.1, XP_011528541.1, XP_005261713.1, XP_006724333.1, XP_011528542.1, NP_005027.2, XP_011528543.1, NP_001001928.1, XP_005261712.1

ZINC - World Drugs

PPARA_HUMAN

Guide to Pharmacology - Targets

593

OpenTargets

ENSG00000186951

ENSEMBL

ENSP00000385246, ENST00000402126, ENSP00000385523, ENST00000407236

ZINC - FDA approved

PPARA_HUMAN

ZINC - Substances

PPARA_HUMAN

ZINC - Biogenic

PPARA_HUMAN

ZINC target

Q07869

PRO

Q07869

PDB

3KDU, 1K7L, 3G8I, 6LX9, 6LX8, 7BQ2, 7BQ4, 6LX7, 6L37, 6L36, 7BQ1, 7E5G, 3FEI, 3ET1, 6LX5, 6KB3, 2NPA, 7C6Q, 2ZNN, 6KB2, 1KKQ, 6KAX, 4BCR, 6KB7, 3VI8, 6LXC, 6KB5, 6L96, 5AZT, 6KXX, 2REW, 5HYK, 7BQ3, 1I7G, 3KDT, 6LXA, 7BPZ, 8HUQ, 6KYP, 7BPY, 6LX6, 6L38, 7E5H, 7E5I, 8HUN, 6LX4, 7BQ0, 6KB4, 6KAZ, 4CI4, 6KB1, 6KB9, 6KBA, 6KAY, 6KB0, 2P54, 6KB8, 6LXB, 6KB6, 8HUK, 3SP6, 7E5F, 6KXY

ZINC - Investigational

PPARA_HUMAN

ZINC - Metabolites

PPARA_HUMAN

HPA

ENSG00000186951-PPARA

Pharos - Targets

Q07869

ZINC - Predictions - Purchasable

PPARA_HUMAN

HMDB Protein

HMDBP02209

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.658	3
UniProt:Q9Y618 NCOR2	2	NCOR2 [nucleoplasm] (R-HSA-442469) monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904)	0.646	3
UniProt:Q13133 NR1H3	1	NR1H3 [nucleoplasm] (R-HSA-8854957)	0.611	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:P06307 CCK	1	CCK [extracellular region] (R-HSA-388539)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P02768-3 ALB			0.556	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.556	3
UniProt:Q3L8U1-3 CHD9			0.524	2
UniProt:P0DTD1-PRO_0000449633 REP			0.488	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2

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