Reactome | SPSB3 [cytosol]

SPSB3 [cytosol]

Stable Identifier

R-HSA-400242

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SPRY domain-containing SOCS box protein 3, SPSB3_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        CUL5-box protein [cytosol] (Homo sapiens)
        
        SPSB3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6PJ21 SPSB3

Gene Names

SPSB3, C16orf31, SSB3

Chain

chain:1-355

Reference Genes

BioGPS Gene:90864 SPSB3

COSMIC (genes):SPSB3 SPSB3

CTD Gene:90864 SPSB3

dbSNP Gene:90864 SPSB3

ENSEMBL:ENSG00000162032 SPSB3

ENSEMBL_homo_sapiens_GENE:ENSG00000162032.16 SPSB3

HGNC:30629 SPSB3

KEGG Gene (Homo sapiens):90864 SPSB3

Monarch:90864 SPSB3

NCBI Gene:90864 SPSB3

OMIM:611659 SPSB3

UCSC:Q6PJ21 SPSB3

Reference Transcript

Other Identifiers

11716731_a_at

11750057_a_at

11755340_a_at

16822815

221769_PM_at

221769_at

3676135

3676136

3676138

3676139

3676140

3676142

3676144

3676146

3676147

3676151

3676152

3676155

46256_PM_at

46256_at

7998590

90864

A_23_P330532

A_23_P330537

A_23_P3496

A_33_P3235716

GE87621

GO:0005515

GO:0005829

GO:0016567

GO:0019005

GO:0030163

GO:0036211

GO:0043161

HMNXSV003032479

Hs.7247.0.S1_3p_s_at

ILMN_1682864

PH_hs_0027064

TC16000760.hg

Participates

as a member of

CUL5-box protein [cytosol] (Homo sapiens)

Inferred To

spsb3 [cytosol] (Xenopus tropicalis)

Dmel\CG10516 [cytosol] (Drosophila melanogaster)

Spsb3 [cytosol] (Mus musculus)

Spsb3 [cytosol] (Rattus norvegicus)

SPSB3 [cytosol] (Bos taurus)

SPSB3 [cytosol] (Canis familiaris)

SPSB3 [cytosol] (Dictyostelium discoideum)

SPSB3 [cytosol] (Gallus gallus)

SPSB3 [cytosol] (Sus scrofa)

LOC559863 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_543137.2, NP_001311010.1

OpenTargets

ENSG00000162032

GeneCards

Q6PJ21

HPA

ENSG00000162032-SPSB3

Ensembl

ENST00000301717, ENST00000566339, ENSP00000457206, ENSP00000301717, ENSG00000162032

PRO

Q6PJ21

Pharos - Targets

Q6PJ21

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2