BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins

Stable Identifier
R-HSA-400267
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins
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Polyubiquitination of PER proteins is directed by the Beta-TrCP1 component of SCF E3 ubiquitin ligase. The polyubiquitinated PER proteins are recognized and degraded by the 26S proteasome. Degradation of PER proteins occurs during the night and is necessary to allow new transcription of BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) targets in the morning during the circadian cycle.

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Catalyst Activity

ubiquitin-protein transferase activity of BTRC:CUL1:SKP1 [cytosol]

Physical Entity
BTRC:CUL1:SKP1 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Inferred From
Per proteins are ubiquitinylated (Mus musculus)
Authored
May, B  (2009-05-18)
Reviewed
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2009-03-24)
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