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RORA [nucleoplasm]
Stable Identifier
R-HSA-400325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor ROR-alpha, RORA_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
Expression of BMAL1 (ARNTL) (Homo sapiens)
RORA:Coactivator:ARNTL gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Expression of NR1D1 (REV-ERBA) (Homo sapiens)
RORA:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Circadian clock (Homo sapiens)
Expression of BMAL (ARNTL), CLOCK, and NPAS2 (Homo sapiens)
RORA and EP300 bind NPAS2 gene (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,B,C positively regulates expression and NR1D1 (REV-ERBA) negatively regulates expression of BMAL1 (ARNTL) (Homo sapiens)
RORA,B,C [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,B,C:Coactivator:BMAL1 gene [nucleoplasm] (Homo sapiens)
RORA,B,C [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,B,C, EP300, PPARGC1A, NRIP1 bind BMAL1 (ARNTL) gene (Homo sapiens)
RORA,B,C [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,B,C:Coactivator:BMAL1 gene [nucleoplasm] (Homo sapiens)
RORA,B,C [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,C and coactivators bind the CLOCK gene (Homo sapiens)
RORA,C:Coactivators:CLOCK gene [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK (Homo sapiens)
RORA,C:Coactivators:CLOCK gene [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes (Homo sapiens)
Phosphorylated BMAL1:CLOCK positively regulates expression of RORA (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression (Homo sapiens)
Expression of Carnitine O-palmitoyltransferase 1 CPT1A (Homo sapiens)
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Expression of SREBF1 (SREBP1) (Homo sapiens)
RORA:EP300:SREBF1 gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA and EP300 bind the SREBF1 (SREBP1) gene (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA:EP300:SREBF1 gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene (Homo sapiens)
RORA,C:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C:Coactivator [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA) (Homo sapiens)
RORA,C:Coactivator:NR1D1 gene [nucleoplasm] (Homo sapiens)
RORA,C:Coactivator [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-MED1 Coactivator Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
NR-MED1 Coactivator Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of Carnitine O-palmitoyltransferase 1 CPT1A (Homo sapiens)
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
RORA and PPARA positively regulate and NR1D1 negatively regulates expression of NPAS2 (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)
RORA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35398 RORA
Gene Names
RORA, NR1F1, RZRA
Chain
chain:1-523
Reference Genes
COSMIC (genes):RORA RORA
dbSNP Gene:6095 RORA
ENSEMBL:ENSG00000069667 RORA
Participates
as an input of
PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
RORA and EP300 bind the Carnitine O-palmitoyltransferase 1 (CPT1A) gene (Homo sapiens)
RORA and EP300 bind the SREBF1 (SREBP1) gene (Homo sapiens)
RORA and EP300 bind NPAS2 gene (Homo sapiens)
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
RORA,RORC [nucleoplasm] (Homo sapiens)
RORA,B,C [nucleoplasm] (Homo sapiens)
as a component of
RORA:EP300:CPT1A gene [nucleoplasm] (Homo sapiens)
RORA:EP300:SREBF1 gene [nucleoplasm] (Homo sapiens)
RORA:EP300:NPAS2 gene [nucleoplasm] (Homo sapiens)
RORA:Coactivator [nucleoplasm] (Homo sapiens)
as an output of
Phosphorylated BMAL1:CLOCK positively regulates expression of RORA (Homo sapiens)
Other forms of this molecule
polySUMO2-K240-RORA [nucleoplasm]
monoSUMO1-K240-RORA [nucleoplasm]
Inferred To
Rora [nucleoplasm]
(Mus musculus)
Rora [nucleoplasm]
(Rattus norvegicus)
nhr-23 [nucleoplasm]
(Caenorhabditis elegans)
RORA [nucleoplasm]
(Bos taurus)
RORA [nucleoplasm]
(Canis familiaris)
RORA [nucleoplasm]
(Gallus gallus)
RORA [nucleoplasm]
(Sus scrofa)
Hr3 [nucleoplasm]
(Drosophila melanogaster)
roraa [nucleoplasm]
(Danio rerio)
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P62195 PSMC5
2
PSMC5 [cytosol]
(R-HSA-68780)
PSMC5 [nucleoplasm]
(R-HSA-174312)
0.553
2
UniProt:P51843 NR0B1
0.508
2
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