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FFAR1 [plasma membrane]
Stable Identifier
R-HSA-400441
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Free fatty acid receptor 1, GPR40
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
FFAR1 binds fatty acids (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
FFAR1 binds rosiglitazone (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
FFAR1:rosiglitazone [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands activate Gq (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Glucagon-like Peptide 1 is secreted from intestinal L cells (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Glucose-dependent Insulinotropic Polypeptide is secreted from intestinal K cells (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Free fatty acid receptors (Homo sapiens)
Receptor FFAR1 binds free fatty acids (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
FFAR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14842 FFAR1
Gene Names
FFAR1, GPR40
Chain
chain:1-300
Reference Genes
BioGPS Gene:2864 FFAR1
COSMIC (genes):FFAR1 FFAR1
CTD Gene:2864 FFAR1
dbSNP Gene:2864 FFAR1
ENSEMBL:ENSG00000126266 FFAR1
ENSEMBL_homo_sapiens_GENE:ENSG00000126266.4 FFAR1
HGNC:4498 FFAR1
KEGG Gene (Homo sapiens):2864 FFAR1
Monarch:2864 FFAR1
NCBI Gene:2864 FFAR1
OMIM:603820 FFAR1
UCSC:O14842 FFAR1
Reference Transcript
RefSeq:NM_005303.2 FFAR1
Other Identifiers
11726290_a_at
11732786_at
11754830_a_at
1561507_PM_at
1561507_at
16861010
204581_PM_at
204581_at
217422_3p_s_at
217422_PM_s_at
217422_s_at
231761_PM_at
231761_at
2864
3830384
3830385
3830386
3830387
3830388
3830389
3830390
3830391
3830392
3830393
3830394
3830395
3830396
3830413
3830414
3830415
3830416
3830418
38521_PM_at
38521_at
38522_s_at
4853636C_3p_s_at
52277_at
8027854
A_14_P131478
A_23_P209055
A_23_P39356
GE79551
GE81067
GO:0004930
GO:0005886
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0008289
GO:0016020
GO:0023052
GO:0030073
GO:0032024
GO:0032691
GO:0042593
GO:0045125
GO:0051928
GO:0060089
GO:0070542
GO:0099105
GO:1990806
HMNXSV003017076
HMNXSV003039199
HMNXSV003054858
Hs.171763.1.S1_3p_s_at
Hs.248127.0.S1_3p_at
Hs2.407586.1.S1_3p_at
ILMN_1756285
ILMN_1792075
PH_hs_0013155
PH_hs_0023308
TC19000466.hg
TC19002100.hg
X59350_at
g4502650_3p_at
g4502650_3p_s_at
p8696
Participates
as a component of
FFAR1:rosiglitazone [plasma membrane] (Homo sapiens)
FFAR1:FFAR1 ligands [plasma membrane] (Homo sapiens)
as an input of
FFAR1 binds rosiglitazone (Homo sapiens)
FFAR1 binds fatty acids (Homo sapiens)
Receptor FFAR1 binds free fatty acids (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
Inferred To
Ffar1 [plasma membrane]
(Mus musculus)
Ffar1 [plasma membrane]
(Rattus norvegicus)
FFAR1 [plasma membrane]
(Bos taurus)
FFAR1 [plasma membrane]
(Canis familiaris)
Cross References
RefSeq
NP_005294.1
ZINC - World Drugs
FFAR1_HUMAN
Guide to Pharmacology - Targets
225
OpenTargets
ENSG00000126266
ZINC - Substances
FFAR1_HUMAN
ZINC target
O14842
ZINC - Biogenic
FFAR1_HUMAN
PRO
O14842
PDB
8EJK
,
5TZY
,
8EIT
,
5KW2
,
8EJC
,
4PHU
,
5TZR
ZINC - Investigational
FFAR1_HUMAN
ZINC - Metabolites
FFAR1_HUMAN
HPA
ENSG00000126266-FFAR1
GeneCards
O14842
Ensembl
ENST00000246553
,
ENSG00000126266
,
ENSP00000246553
Pharos - Targets
O14842
ZINC - Predictions - Purchasable
FFAR1_HUMAN
HMDB Protein
HMDBP02036
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