PIAS1 SUMOylates SAFB with SUMO1

Stable Identifier
R-HSA-4085347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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PIAS1 SUMOylates SAFB at lysine-231 and lysine-294 with SUMO1 (Garee et al. 2011). SUMOylation of SAFB is required for co-repressor activity of SAFB at promoters regulated by the estrogen receptor (ER). In contrast, SUMOylated SAFB increases transcription of genes encoding ribosomal proteins (Liu 2015).
Literature References
PubMed ID Title Journal Year
21527249 Co-repressor activity of scaffold attachment factor B1 requires sumoylation

Oesterreich, S, Garee, JP, Meyer, R

Biochem. Biophys. Res. Commun. 2011
25800734 The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing

Guan, X, Banerjee, T, Liu, HW, Parvin, JD, Freitas, MA

Nucleic Acids Res. 2015
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS1 [nucleoplasm]

Orthologous Events
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