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NRIP1 [nucleoplasm]
Stable Identifier
R-HSA-4086031
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor-interacting protein 1, NRIP1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9UBC3 DNMT3B
Expand all
Circadian Clock (Homo sapiens)
RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis (Homo sapiens)
NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (Homo sapiens)
NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)
NRIP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48552 NRIP1
Gene Names
NRIP1
Chain
chain:1-1158
Reference Genes
BioGPS Gene:8204 NRIP1
COSMIC (genes):NRIP1 NRIP1
CTD Gene:8204 NRIP1
dbSNP Gene:8204 NRIP1
ENSEMBL:ENSG00000180530 NRIP1
HGNC:8001 NRIP1
KEGG:hsa:8204 NRIP1
Monarch:8204 NRIP1
NCBI Gene:8204 NRIP1
OMIM:602490 NRIP1
UCSC:P48552 NRIP1
Reference Transcript
RefSeq:XM_011529752.1 NRIP1
RefSeq:XM_017028475.1 NRIP1
RefSeq:XM_017028473.1 NRIP1
RefSeq:XM_011529747.1 NRIP1
RefSeq:XM_011529749.2 NRIP1
RefSeq:NM_003489.3 NRIP1
RefSeq:XM_011529751.2 NRIP1
RefSeq:XM_017028474.1 NRIP1
RefSeq:XM_017028476.1 NRIP1
RefSeq:XM_005261063.3 NRIP1
RefSeq:XM_005261065.3 NRIP1
RefSeq:XM_011529748.2 NRIP1
Other Identifiers
11720153_s_at
11720154_at
16924268
202599_PM_s_at
202599_s_at
202600_PM_s_at
202600_s_at
3925640
3925641
3925642
3925643
3925644
3925645
3925646
3925651
3925656
3925659
3925665
3925667
3925671
40088_at
8069553
8204
A_23_P211007
A_33_P3251430
GE477460
GE54838
GO:0000118
GO:0000122
GO:0000785
GO:0000978
GO:0001543
GO:0001650
GO:0003677
GO:0003712
GO:0003713
GO:0003714
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005829
GO:0006355
GO:0006357
GO:0007623
GO:0016607
GO:0016922
GO:0019915
GO:0022414
GO:0030331
GO:0030728
GO:0032922
GO:0035259
GO:0042826
GO:0042974
GO:0043226
GO:0045944
GO:0046965
GO:0048511
GO:0060090
GO:0071392
GO:0140110
HMNXSV003031998
Hs.155017.0.S1_3p_a_at
ILMN_1718629
TC21000288.hg
X84373_at
g4505454_3p_a_at
Participates
as an input of
NR1H2 or NR1H3, NRIP1 bind the SCD gene (Homo sapiens)
NR1H2,3, NRIP1 bind the FASN gene (Homo sapiens)
NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene (Homo sapiens)
NR1H3, NRIP1 bind the PCK1 gene (Homo sapiens)
ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators (Homo sapiens)
PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)
RORA, EP300, PPARGC1A bind NR1D1 gene (Homo sapiens)
RORA, EP300, PPARGC1A, NRIP1 bind ARNTL (BMAL1) gene (Homo sapiens)
as a component of
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SCD gene [nucleoplasm] (Homo sapiens)
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:FASN gene [nucleoplasm] (Homo sapiens)
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SREBF1 gene [nucleoplasm] (Homo sapiens)
NRIP1:NR1H3:RXR:NR1H3 ligand:PCK1 gene [nucleoplasm] (Homo sapiens)
ESR1:ESTG:PGR:P4:FOXA1:GATA3:TLE3:NRIP:EP300 [nucleoplasm] (Homo sapiens)
RORA:Coactivator [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K756,K1154-NRIP1 [nucleoplasm]
Inferred To
NRIP1 [nucleoplasm]
(Bos taurus)
NRIP1 [nucleoplasm]
(Gallus gallus)
NRIP1 [nucleoplasm]
(Sus scrofa)
nrip1 [nucleoplasm]
(Xenopus tropicalis)
Nrip1 [nucleoplasm]
(Mus musculus)
Nrip1 [nucleoplasm]
(Rattus norvegicus)
nrip1a [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
XP_011528053.1
,
XP_011528054.1
,
XP_011528050.1
,
XP_016883963.1
,
XP_011528051.1
,
XP_016883964.1
,
XP_005261120.1
,
NP_003480.2
,
XP_016883965.1
,
XP_005261122.1
,
XP_016883962.1
,
XP_011528049.1
OpenTargets
ENSG00000180530
ENSEMBL
ENSP00000383063
,
ENST00000318948
,
ENSP00000327213
,
ENSP00000383060
,
ENST00000400202
,
ENST00000400199
HPA
ENSG00000180530-NRIP1
PRO
P48552
Pharos - Targets
P48552
GlyGen
P48552
PDB
6G05
,
5NTW
,
5NTI
,
2GPO
,
2GPP
,
6G07
,
4S14
,
5NTN
,
4S15
,
5NU1
,
6FZU
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.712
4
UniProt:Q13363 CTBP1
3
CTBP1 [nucleoplasm]
(R-HSA-212372)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
0.683
3
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.666
4
UniProt:Q13642 FHL1
0.633
6
UniProt:O95751 LDOC1
0.621
3
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.602
4
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.564
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P62508-3 ESRRG
0.556
3
UniProt:P10276-2 RARA
0.556
3
UniProt:O15145 ARPC3
1
ARPC3 [cytosol]
(R-HSA-200812)
0.556
3
UniProt:Q6PI77 GASP3
0.556
3
UniProt:Q96KN3 PKNX2
0.556
3
UniProt:P43363 MAGAA
0.527
2
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.508
2
UniProt:P26358 DNMT1
2
DNMT1 [nucleoplasm]
(R-HSA-212181)
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
0.499
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.489
2
UniProt:Q9Y6K1 DNMT3A
2
DNMT3A [nucleoplasm]
(R-HSA-212287)
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
0.462
3
UniProt:Q9UBC3 DNMT3B
2
DNMT3B [nucleoplasm]
(R-HSA-212316)
SUMO1-K-DNMT3B [nucleoplasm]
(R-HSA-4655334)
0.462
3
UniProt:Q92731 ESR2
5
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
0.462
2
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