SUMOylation of NPM1 with SUMO1

Stable Identifier
R-HSA-4086088
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of NPM1 with SUMO1
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NPM1 (Nucleophosmin, B23) is SUMOylated at lysine-263 with SUMO1 (Liu et al. 2007). SUMOylation enhances binding of NPM1 to Rb and enhances nuclear residency of NPM1.
Literature References
PubMed ID Title Journal Year
17535915 Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival

Liu, X, Shinmura, K, Kang, S, Ma, Z, Jang, SW, Ye, K, Liu, Z, Fukasawa, K, Chen, J, Dong, S

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of NPM1 with SUMO1 (Bos taurus)
SUMOylation of NPM1 with SUMO1 (Gallus gallus)
SUMOylation of NPM1 with SUMO1 (Mus musculus)
SUMOylation of NPM1 with SUMO1 (Rattus norvegicus)
SUMOylation of NPM1 with SUMO1 (Sus scrofa)
SUMOylation of NPM1 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-08-05)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-07)
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