Dentin phosphoprotein binds integrin alphaVbeta1

Stable Identifier
R-HSA-4086132
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
DSPP(463-1301) binds
ReviewStatus
5/5
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Dentin phosphoprotein binds integrin alphaVbeta1
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DPP (also called “phosphophoryn”) is a highly acidic protein and is the major noncollagenous matrix component of dentin (13,–,15). The molecule is so-called because it is considered to be a “phosphate carrier” (16). DPP is exceedingly rich in aspartic acid and serine residues ((DSS)n), and about 90% of the serine residues are phosphorylated (17, 18). This enables DPP to have a strong affinity for calcium ion, and thus it significantly promotes the growth of hydroxyapatite crystals when bound to collagen fibrils in vitro.
Literature References
PubMed ID Title Journal Year
22134916 Dentin phosphoprotein (DPP) activates integrin-mediated anchorage-dependent signals in undifferentiated mesenchymal cells

Eapen, A, Ramachandran, A, George, A

J. Biol. Chem. 2012
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Orthologous Events
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Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2013-08-07)
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