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p-S252-BORA [cytosol]
Stable Identifier
R-HSA-4086411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
AURKA phosphorylates PLK1 (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
p-S252-BORA [cytosol] (Homo sapiens)
p-S252-BORA:p-T210-PLK1 [cytosol] (Homo sapiens)
p-S252-BORA [cytosol] (Homo sapiens)
BORA binds PLK1 and AURKA (Homo sapiens)
Centrosome:p-T288-AURKA:p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
p-S252-BORA [cytosol] (Homo sapiens)
p-S252-BORA [cytosol] (Homo sapiens)
CDK1 phosphorylates BORA (Homo sapiens)
p-S252-BORA [cytosol] (Homo sapiens)
PLK1 phosphorylates BORA (Homo sapiens)
p-S252-BORA:p-T210-PLK1 [cytosol] (Homo sapiens)
p-S252-BORA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6PGQ7 BORA
Gene Names
BORA, C13orf34
Chain
chain:1-559
Reference Genes
BioGPS Gene:79866 BORA
COSMIC (genes):BORA BORA
CTD Gene:79866 BORA
dbSNP Gene:79866 BORA
ENSEMBL:ENSG00000136122 BORA
ENSEMBL_homo_sapiens_GENE:ENSG00000136122.18 BORA
HGNC:24724 BORA
KEGG Gene (Homo sapiens):79866 BORA
Monarch:79866 BORA
NCBI Gene:79866 BORA
OMIM:610510 BORA
UCSC:Q6PGQ7 BORA
Reference Transcript
RefSeq:NM_001286746.1 BORA
RefSeq:NM_024808.3 BORA
RefSeq:NM_001286747.1 BORA
Other Identifiers
11725785_at
11755874_a_at
11758334_s_at
16775324
219544_PM_at
219544_at
3493405
3493406
3493407
3493408
3493409
3493410
3493414
3493417
3493419
3493423
3493424
3493425
3493426
3493427
3493428
3493429
3493430
3493431
3493435
3493437
3493438
3493439
3493440
7969374
79866
A_14_P121461
A_14_P137554
A_14_P138511
A_14_P138624
GE82953
GO:0000278
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0007010
GO:0007049
GO:0007088
GO:0019901
GO:0032880
GO:0043226
GO:0051301
GO:0060236
GO:0072687
GO:0140014
HMNXSV003017355
HMNXSV003017447
ILMN_1761486
PH_hs_0023813
TC13000270.hg
g13376190_3p_at
Participates
as an output of
CDK1 phosphorylates BORA (Homo sapiens)
as an input of
BORA binds PLK1 and AURKA (Homo sapiens)
as a component of
p-S252-BORA:PLK1 [cytosol] (Homo sapiens)
p-S252-BORA:p-T210-PLK1 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S252,S497,T501-BORA [cytosol]
BORA [cytosol]
Inferred To
phospho-bora [cytosol]
(Danio rerio)
phospho-bora [cytosol]
(Drosophila melanogaster)
phospho-bora [cytosol]
(Xenopus tropicalis)
phospho-BORA [cytosol]
(Bos taurus)
phospho-BORA [cytosol]
(Canis familiaris)
phospho-BORA [cytosol]
(Gallus gallus)
phospho-BORA [cytosol]
(Sus scrofa)
phospho-Bora [cytosol]
(Mus musculus)
phospho-Bora [cytosol]
(Rattus norvegicus)
phospho-spat-1 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 252
Coordinate
252
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001273676.1
,
NP_001273675.1
,
NP_079084.3
OpenTargets
ENSG00000136122
GeneCards
Q6PGQ7
HPA
ENSG00000136122-BORA
Ensembl
ENST00000652266
,
ENSP00000498664
,
ENSP00000498882
,
ENST00000390667
,
ENSP00000375082
,
ENSG00000136122
,
ENST00000651477
PRO
Q6PGQ7
Pharos - Targets
Q6PGQ7
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.848
9
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.656
3
UniProt:Q9GZY0 NXF2
2
NXF2 [cytosol]
(R-HSA-8932924)
NXF2 [nucleoplasm]
(R-HSA-8932926)
0.527
2
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:Q969N2 PIGT
1
PIGT [endoplasmic reticulum membrane]
(R-HSA-162764)
0.527
2
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.527
2
UniProt:P63167 DYNLL1
6
DYNLL1 [ciliary tip]
(R-HSA-5625335)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [cytosol]
(R-HSA-387105)
0.527
2
UniProt:P51530 DNA2
1
DNA2 [nucleoplasm]
(R-HSA-68465)
0.527
2
UniProt:Q7Z6J8 UBE3D
1
UBE3D [cytosol]
(R-HSA-8851647)
0.527
3
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.527
2
UniProt:P56705 WNT4
9
WNT4 [extracellular region]
(R-HSA-517385)
N4GlycoAsn-PalmS WNT4 [extracellular exosome]
(R-HSA-3781964)
N4GlycoAsn-PalmS WNT4 [endocytic vesicle membrane]
(R-HSA-3781978)
WNT4 [endoplasmic reticulum lumen]
(R-HSA-3238297)
N4GlycoAsn-WNT4 [endoplasmic reticulum lumen]
(R-HSA-3238235)
N4GlycoAsn-PalmS WNT4 [endoplasmic reticulum lumen]
(R-HSA-3238347)
N4GlycoAsn-PalmS WNT4 [Golgi lumen]
(R-HSA-3247779)
N4GlycoAsn-PalmS WNT4 [extracellular region]
(R-HSA-3247794)
N4GlycoAsn-PalmS WNT4 [plasma membrane]
(R-HSA-3247809)
0.527
2
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