Reactome | p-T611-FOXM1 [nucleoplasm]

p-T611-FOXM1 [nucleoplasm]

Stable Identifier

R-HSA-4088026

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:P14868 DARS1

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External Reference Information

External Reference

UniProt:Q08050 FOXM1

Gene Names

FOXM1, FKHL16, HFH11, MPP2, WIN

Chain

chain:1-763

Reference Genes

BioGPS Gene:2305 FOXM1

COSMIC (genes):FOXM1 FOXM1

COSMIC (genes):MPP2 FOXM1

CTD Gene:2305 FOXM1

dbSNP Gene:2305 FOXM1

ENSEMBL:ENSG00000111206 FOXM1

HGNC:3818 FOXM1

KEGG:hsa:2305 FOXM1

Monarch:2305 FOXM1

NCBI Gene:2305 FOXM1

OMIM:602341 FOXM1

UCSC:Q08050 FOXM1

Reference Transcript

Other Identifiers

11725441_a_at

11725442_a_at

11734028_a_at

16760048

202580_PM_x_at

202580_x_at

2305

3440599

3440600

3440601

3440602

3440603

3440604

3440605

3440606

3440607

3440608

3440609

3440610

3440612

3440614

3440615

3440616

3440617

3440618

3440619

3440620

3440621

3440622

3440623

3440627

3440628

3440629

3440630

3440631

3440632

3440633

3440634

3440635

34715_at

70225_r_at

7960340

A_23_P151150

GE59391

GE667973

GO:0000086

GO:0000122

GO:0000785

GO:0000977

GO:0000981

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0006281

GO:0006355

GO:0006357

GO:0006978

GO:0008284

GO:0019901

GO:0032873

GO:0042127

GO:0043226

GO:0043565

GO:0045892

GO:0045893

GO:0045944

GO:0046578

GO:0051726

GO:0140110

GO:2000377

GO:2000781

HMNXSV003023971

ILMN_1716400

ILMN_2344971

PH_hs_0026679

TC12001106.hg

U74612_at

g11386144_3p_s_at

Participates

as an input of

as an output of

CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 (Homo sapiens)

as a component of

p-T611-FOXM1:p-T210-PLK1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T611,S730,S739-FOXM1 [nucleoplasm]

FOXM1 [nucleoplasm]

Inferred To

phospho-FOXM1 [nucleoplasm] (Bos taurus)

phospho-FOXM1 [nucleoplasm] (Canis familiaris)

phospho-FOXM1 [nucleoplasm] (Gallus gallus)

phospho-foxm1 [nucleoplasm] (Danio rerio)

phospho-foxm1 [nucleoplasm] (Xenopus tropicalis)

phospho-p-T611-FOXM1 [nucleoplasm] (Sus scrofa)

phospho-Foxm1 [nucleoplasm] (Mus musculus)

phospho-Foxm1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 611

Coordinate

611

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001230017.1, NP_973732.1, NP_001230018.1, NP_973731.1, NP_068772.2

OpenTargets

ENSG00000111206

ENSEMBL

ENST00000361953, ENSP00000342307, ENST00000359843, ENSP00000354492, ENSP00000352901, ENST00000342628

HPA

ENSG00000111206-FOXM1

PRO

Q08050

Pharos - Targets

Q08050

GlyGen

Q08050

PDB

3G73, 7FJ2

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.672	16
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 [nucleoplasm] (R-HSA-201923)	0.612	7
UniProt:Q8N9N5-7 BANP			0.556	3
UniProt:A0A455ZAR2 PNT87			0.556	4
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.544	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.499	2
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.499	2
UniProt:P14868 DARS1	1	DARS [cytosol] (R-HSA-379605)	0.499	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.499	2

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