PLK1 phosphorylates FOXM1

Stable Identifier
R-HSA-4088134
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PLK1 phosphorylates FOXM1
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PLK1 phosphorylates FOXM1 on serine residues S730 and S739 (S715 and S724 in FOXM1B isoform) in the C-terminal transactivation domain (TAD). PLK1-mediated phosphorylation of FOXM1 upregulates FOXM1 transcriptional activity and is crucial for FOXM1 function at G2/M transition (Fu et al. 2008).

Literature References
PubMed ID Title Journal Year
19160488 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z, van Deursen, JM, Li, H, Chen, J, Huang, J, Tindall, DJ, Malureanu, L, Wang, W

Nat. Cell Biol. 2008
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T611-FOXM1:p-T210-PLK1 [nucleoplasm]

Physical Entity
p-T611-FOXM1:p-T210-PLK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PLK1 phosphorylates FOXM1 (Bos taurus)
PLK1 phosphorylates FOXM1 (Canis familiaris)
PLK1 phosphorylates FOXM1 (Danio rerio)
PLK1 phosphorylates FOXM1 (Gallus gallus)
PLK1 phosphorylates FOXM1 (Mus musculus)
PLK1 phosphorylates FOXM1 (Rattus norvegicus)
PLK1 phosphorylates FOXM1 (Sus scrofa)
PLK1 phosphorylates FOXM1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-08-14)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-08-09)
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