SUMOylation of HIPK2 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
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HIPK2 is SUMOylated at lysine-32 with SUMO1. (Lysine-25 is cited by Hofmann et al. 2005 and Gresko et al. 2005, however the sequence motif listed in Hoffmann et al. 2005 corresponds to lysine-32 of the UniProt reference protein. An alternative isoform having lysine-25 is listed as accession AAG35710 in GenBank.) SUMOylation of HIPK2 disrupts interaction of HIPK2 with GROUCHO corepressor, inhibits JNK activation, and inhibits p53-independent antiproliferative function.

Literature References
PubMed ID Title Journal Year
15766567 Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability

Möller, A, Roscic, A, Gresko, E, Schmitz, ML

Biochem. Biophys. Res. Commun. 2005
15958389 Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

Stollberg, N, Hay, RT, Hofmann, TG, Jaffray, E, Will, H

J. Biol. Chem. 2005
Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [cytoplasm]

Orthologous Events
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