PIAS1,3 SUMOylate ESR1 with SUMO1

Stable Identifier
R-HSA-4090408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PIAS1,3 SUMOylate ESR1 (Estrogen Receptor alpha, ER-alpha, ER, NR3A1) at lysines-266,268,299,302,303 with SUMO1 (Sentis et al. 2005). SUMOylation reduces transcription activation by ESR1.

Literature References
PubMed ID Title Journal Year
15961505 Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity

Sentis, S, Le Romancer, M, Bianchin, C, Rostan, MC, Corbo, L

Mol. Endocrinol. 2005
Participants
Participates
Catalyst Activity

SUMO transferase activity of PIAS1,3 [nucleoplasm]

Orthologous Events
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