PIAS1,3 SUMOylate ESR1 with SUMO1

Stable Identifier
R-HSA-4090408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PIAS1,3 SUMOylate ESR1 with SUMO1
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PIAS1,3 SUMOylate ESR1 (Estrogen Receptor alpha, ER-alpha, ER, NR3A1) at lysines-266,268,299,302,303 with SUMO1 (Sentis et al. 2005). SUMOylation reduces transcription activation by ESR1.
Literature References
PubMed ID Title Journal Year
15961505 Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity

Le Romancer, M, Rostan, MC, Corbo, L, Bianchin, C, Sentis, S

Mol. Endocrinol. 2005
Participants
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Output
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as an event of
Catalyst Activity

SUMO transferase activity of PIAS1,3 [nucleoplasm]

Physical Entity
PIAS1,3 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS1,3 SUMOylate ESR1 with SUMO1 (Bos taurus)
PIAS1,3 SUMOylate ESR1 with SUMO1 (Gallus gallus)
PIAS1,3 SUMOylate ESR1 with SUMO1 (Mus musculus)
PIAS1,3 SUMOylate ESR1 with SUMO1 (Rattus norvegicus)
PIAS1,3 SUMOylate ESR1 with SUMO1 (Sus scrofa)
PIAS1,3 SUMOylate ESR1 with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-08-07)
Reviewed
Niskanen, E  (2018-05-09)
Niskanen, E  (2018-08-08)
Created
May, B  (2013-08-14)
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